右心导管术对静脉血中循环内皮细胞的影响及临床意义  

Effect of right heart catheterization on venous endothelial cells and clinic significance

作　　者：方宏[1] 冯义柏[1] 刘坚 方盈 陈志坚[1] 王祥[1] 李裕舒[1] 

机构地区：[1]同济医科大学心血管病研究所同济医科大学附属协和医院心内科,武汉430022 [2]湖北黄石冶钢医院心内科

出　　处：《临床心血管病杂志》2000年第8期350-351,共2页Journal of Clinical Cardiology

摘　　要：目的 :观察右心导管术对静脉内皮的影响 ,明确其机制及临床意义。方法 :1 2例行右心导管术的患者 ,手术前后分别采静脉血 4.5 ml,用五步法分离脱落的静脉内皮细胞 ,免疫荧光法鉴别 ,光镜计数。结果 :右心导管术后循环内皮细胞计数明显高于术前 (P <0 .0 0 1 ) ,但其数量变化与手术时间无线性关系。结论 :右心导管术对静脉内皮有机械损伤。Objective:To observe the effect of right heart catheterization on venous blood endothelium cells and clinic significance.Method: 4.5 ml blood were obtained from 12 cases who were performed right heart catheterization before and after operation.Isolation was carried out according to the five stage method.These cells were confirmed by immunofluorescence and counted under optical microscope.Result:The venous endothelial cells after operation was significantly higher than those before operation.There wasn′t linear correlation between the number change of circulating endothelial cells and operating duration.Conclusion:Right heart catheterization may injure venous endothelium.

关 键 词：循环内皮细胞 右心导管术 静脉内皮细胞 

分 类 号：R654.2[医药卫生—外科学]