细胞因子及内皮细胞游走与川崎病发病的关系  

A study on cytokines activity and endothelial cells migration in Kawasaki disease

作　　者：刘亚黎[1] 胡晓华[1] 黄显香 

机构地区：[1]同济医科大学附属协和医院小儿科,武汉430022

出　　处：《临床心血管病杂志》2000年第8期367-368,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨川崎病的发病与细胞因子、内皮细胞游走的关系。方法 :用 EL ISA双抗夹心法和改良Boyden法 ,检测 2 8例川崎病急性期及丙种球蛋白治疗后患儿的血浆细胞因子含量变化及其对内皮细胞游走的影响 ,并与 1 0例健康儿童对照。结果 :在川崎病急性期时 ,白细胞介素 1 β(IL- 1 β)、IL- 6、肿瘤坏死因子 α(TNF- α)、γ干扰素 (IFN-γ)等蛋白含量明显增高 ,用丙种球蛋白治疗后下降 ;试管内加入上述细胞因子使得内皮细胞的游走明显增加。结论 :川崎病急性期时 ,细胞因子的产生具有加速内皮细胞游走 ,破坏动脉内膜 ,诱发动脉炎的作用 。Objective:To investigate the cytokines activity and human umbilical vein cell migration (tHUE) in Kawasaki disease.Method:The levels of cytokines and migration of endothelial cells in plasma from 28 patients with Kawasaki disease were examined by ELISA and modified Boyden chamber methods and compared with those of 10 normal children.Result:IFN γ,TNF α,IL 1β and IL 6 levels were significantly higher than normal controls.Also the plasma markedly enhanced the migration of tHUE cells.Migration index showed decrease after γ globulin treatment.Conclusion:Cytokines are important in destroying vessel walls with Kawasaki disease by enhancing the migration of endothelial cells;γ globulin may be therapeutical effect for this disease by suppressing this endothelial cell migration.

关 键 词：川崎病 丙种球蛋白 细胞因子 内皮细胞游走 

分 类 号：R725.970.2[医药卫生—儿科]