尿α1微球蛋白与早产儿SNAP评分的相关性分析  

Relationship between Urinary α1-Microglobulin Level and Severity of Illness in Premature Infants

作　　者：严洁[1] 肖志辉[1] 李艳红[1] 

机构地区：[1]苏州大学附属儿童医院新生儿科,江苏省苏州市215003

出　　处：《中华全科医学》2013年第7期1020-1020,1072,共2页Chinese Journal of General Practice

摘　　要：目的探讨早产新生儿尿中α1微球蛋白(α1-MG)水平与早产儿疾病危重程度的关系。方法采用免疫比浊法测定86例生后24 h之内的早产新生儿(胎龄28～37周)尿中α1-MG含量,采用新生儿急性生理学评分标准(SNAP)评估患儿疾病危重程度,并分析尿α1-MG含量与新生儿急性生理学评分(SNAP)的关系。结果 86例早产新生儿的尿α1-MG含量与其胎龄及出生体重呈负相关关系(P值均<0.05),与SNAP分值呈正相关关系(P值<0.05)。结论尿α1-MG测定作为一种简捷快速、无损伤的临床实验室检测指标,其含量水平随着肾功能的逐渐发育成熟而降低,并随早产儿疾病危重程度的加重而增高,尿α1-MG含量对于早产儿病情危重程度的评估有良好的应用价值。Objective To determine the relationship between urinary α1-microglobulin（α1-MG） level and the severity of ill- ness evaluated by score for neonatal acute physiology （SNAP） in premature infants. Methods We determined the uIine α1-MG by immune turbidimetry, and calculated SNAP for each infant during the first 24 hours of admission, then the relationship between the score of SNAP and ctl-MG were assessed. Results There were a negative correlation between α1-MG level and the gestation or birth weight （ P 〈 0.05 ）. Moreover,α1-MG was positively correlated with the score of SNAP （ P 〈 0.05 ）. Conclusion Our study suggests that α1-MG level is closely related to the score of SNAP.

关 键 词：尿Α1微球蛋白 新生儿急性生理学评分 早产儿 

分 类 号：R722.1[医药卫生—儿科]