霉酚酸酯(MMF)联合中药治疗狼疮肾炎临床观察  

Clinical observation of mycophenolate mofetil combined with traditional Chinese medicine in the treatment of lupus nephritis

作　　者：崔明晓[1] 陈彤[1] 

机构地区：[1]济南市中医医院,山东济南250012

出　　处：《药学研究》2013年第5期304-306,共3页Journal of Pharmaceutical Research

摘　　要：目的比较霉酚酸酯(mycophenolate mofeti,MMF)和霉酚酸酯加中药自拟方组治疗狼疮肾炎(lupusne-phritis,LN)的近期及远期疗效、不良反应。方法 62例LN患者随机分为两组,对照组31例,治疗组31例,对照组采用MMF联合激素治疗,治疗组采用MMF加中药自拟方治疗,对患者的24 h尿蛋白定量、肝肾功能、副作用进行比较。结果两组治疗LN均能降低蛋白尿,改善肾功能,提高血浆白蛋白,有效地控制LN,两者无显著性差异。但治疗组有效率高于对照组,差异有统计学意义(P<0.05)。且胃肠道症状治疗组显著低于对照组(P<0.05)。结论经MMF加中药自拟方治疗后有效率高于MMF组,而且副作用少,显示MMF加中草药对LN治疗具有一定的优越性。Objective To observe short - term, ong - term efficacy, adverse reactions and safety through mycophenolate mofetil （MMF） and self traditional Chinese medicine treatment for lupus nephritis （ LN ）. Methods 62 patients with LN were randomly divided into two groups,the control group and the treatment group. The patients in the control group were treated through MMF combined hormone therapy,while the patients in the treatment group were treated through self tradi- tional Chinese medicine plus MMF, and 24 h urinary protein, the patient ＇ s liver and kidney function, side effects were com-pared. Results Treatment for LN can reduce proteinuria and improve kidney function,increase plasma albumin. There was no significant difference between two groups. Efficiency in the treatment group was higher, the difference was statistically sig- nificant （ P 〈 0.05 ）. Gastrointestinal symptoms in the treatment group was significantly lower than these in the control group （ P 〈 0.05 ）. There was no significant difference for the rest of adverse reactions （ P 〉 0.05 ）. Conclusion MMF and tradi- tional Chinese medicine treatment more efficient than the MMF group, and MMF plus Chinese herbal medicine treatment of LN has certain advantages with less side effects.

关 键 词：狼疮肾炎 霉酚酸酯 中药 

分 类 号：R969.4[医药卫生—药理学]