复方维A酸凝胶治疗寻常痤疮有效性和安全性研究  

Efficacy and Safety of Compound Tretinoin Gel in Treatment of Acne Vulgaris

作　　者：庄婕[1] 晁磊[2] 崔燕[1] 

机构地区：[1]山东省生物药物研究院,山东济南250101 [2]山东大学附属济南市中心医院,山东济南250013

出　　处：《食品与药品》2013年第3期162-164,共3页Food and Drug

摘　　要：目的评价复方维A酸凝胶治疗寻常痤疮的有效性和安全性。方法采用多中心、随机、盲法、阳性药平行对照的临床试验。结果经8周治疗,停药时对炎性损害的有效率试验组为82.20%,对照组为79.66%;对非炎性损害的有效率分别为59.29%和66.36%;对所有损害的有效率分别为74.58%和72.03%。两组比较差异均无统计学意义。结论复方维A酸凝胶治疗寻常痤疮有效、安全。Objective To evaluate the efficacy and safety of Compound Tretinoin Gel in the treatment of acne vulgaris compared with commercial 0.025 % Tretinoin Cream. Methods A multi-center, randomized, double-blind, positive controlled clinical trial was conducted. Results After 8 weeks, the effectiveness for inflammatory injury of treatment group and control group were 82.20 % and 79.66 %, respectively, the effectiveness for non-inflammatory injury were 59.29 % and 66.36 %, respectively, the total effectiveness for injury were 74.58 % and 72.03 %, respectively. There was no statistical difference between two groups. Conclusion Compound Tretinoin Gel can be effective and safe in the treatment of acne vulgaris.

关 键 词：复方维A酸凝胶 维A酸乳膏 寻常痤疮 

分 类 号：R969.4[医药卫生—药理学]