预防全椎板切除后椎管再狭窄的实验研究  

Prevention of recurrent stenosis after total laminectomy:an experimental study in rabbits

作　　者：沈康平[1] 陈正形[2] 李家顺[1] 贾连顺[1] 宋海涛[1] 顾晓民 来茂德 

机构地区：[1]第二军医大学长征医院骨科,上海200003 [2]浙江医科大学附属第二医院骨科 [3]杭州市第二医院骨科

出　　处：《第二军医大学学报》2000年第7期636-638,共3页Academic Journal of Second Military Medical University

基　　金：上海市医学领先专业重点学科基金资助项目 !( 1995- 0 0 8;1998- - 0 0 8)

摘　　要：目的 :探讨多孔磷酸钙人工椎板预防全椎板切除后椎管再狭窄的效果。方法 :以家兔为动物模型 ,行全椎板切除术后多孔磷酸钙人工椎板置换 ,大体观察、切片病理观察、CT扫描和三维结构重建 ,计算机图像分析定量测定椎管面积和矢状径。结果 :多孔磷酸钙人工椎板节段的椎管面积和矢状径比空白节段明显增大 ( P<0 .0 1) ,与正常对照节段无显著性差异。结论 :多孔磷酸钙人工椎板能有效地预防椎板再生后椎管狭窄 。Objective: To study the prevention of recurrent stenosis after laminectomy in rabbits. Methods: Porous calicium phosphate artificial lamina was used in rabbits after total laminectomy. Evaluation was done by gross anatomical appearance, microscopical evaluation, CT scan and computed imaging analysis. Results: The area and sagittal diameter of spinal canal of lamina implanted sites was larger than unimplanted ites( P <0.01), and no significant difference was found between the implanted group and control group. Conclusion: The porous calcium phosphate artificial lamina can prevent recurrent stenosis after laminectomy. Bone regeneration after laminectomy may cause spinal stenosis, which is related with the invasion of fibrous tissue.

关 键 词：全椎板切除术 椎管再狭窄 多孔磷酸钙 骨再生 

分 类 号：R681.506[医药卫生—骨科学]