全椎板切除后椎板再生机制的实验研究  

Mechanism of bone regeneration after total laminectomy: an experimental study in rabbits

作　　者：沈康平[1] 李家顺[1] 贾连顺[1] 陈正形[2] 顾晓民 宋海涛[1] 来茂德[4] 

机构地区：[1]第二军医大学长征医院骨科,上海200003 [2]浙江医科大学第二医院骨科 [3]杭州市第二医院骨科 [4]浙江医科大学病理科

出　　处：《第二军医大学学报》2000年第7期639-641,共3页Academic Journal of Second Military Medical University

基　　金：上海市医学领先专业重点学科基金资助项目! ( 1995- - 0 0 8;1998- - 0 0 8)

摘　　要：目的 :探讨全椎板切除后椎板再生的机制。方法 :以家兔为动物模型行全椎板切除术后 ,肉眼观察、切片病理观察、CT扫描和三维结构重建 ,计算机图像分析定量测定。结果 :全椎板切除后在椎板缺损部位纤维化 ,首先是在骨组织缺损的边缘软骨组织形成 ,然后再演变为骨组织 ,最后形成再生椎板。椎板再生后椎管面积和矢状径比正常椎管小 ( P<0 .0 1)。结论 :椎板再生是软骨内骨化的过程 ,并证实了椎板再生的方式是骨组织逐渐再生。再生的椎板导致椎管狭窄 ,椎管狭窄与纤维组织的侵入有关。Objective: To study the mechanism of bone regeneration and spinal stenosis after laminectomy in rabbits. Methods: The results were evaluated by gross anatomical appearance, microscopical evaluation, CT scan and computed imaging analysis. Results: There was fibrous tissue in the defect of lamina after laminectomy. First formed cartilaginous tissue in fibrous, and then evolved into osseous tissues, and finally into. regenerate lamina. The area and sagittal diameter of spinal canal of test segments was smaller than normal segments ( P <0.01). Conclusion: Bone regeneration after laminectomy is the process of endochondral ossification. The type of bone regeneration is identified. Bone regeneration post laminectomy causes spinal stenosis which relates to the invasion of fibrous tissue.

关 键 词：全椎板切除术 椎管再狭窄 椎板再生 

分 类 号：R681.506[医药卫生—骨科学]