超声消融联合自体干细胞移植治疗下肢动脉硬化性闭塞症的临床观察  

Ultrasound ablation and autologous transplantation of bone marrow mononuclear cells for treating patients with arteriosclerosis obliterans

作　　者：王寅冬[1] 王爱林[1] 

机构地区：[1]黑龙江省医院周围血管病科,黑龙江哈尔滨150001

出　　处：《中国校医》2013年第5期366-367,369,共3页Chinese Journal of School Doctor

摘　　要：目的观察血管内超声消融联合自体骨髓干细胞移植治疗下肢动脉硬化性闭塞症的疗效。方法 56例下肢动脉粥样硬化闭塞症的患者,男33例,女23例;平均年龄63岁。手术首先抽取自体骨髓干细胞260mL,分离出单个核细胞悬浊液40 mL。采用经皮股动脉穿刺或显露切开插入超声消融导管,在动脉造影监视下进行血管内超声消融,而后将干细胞悬浊液注射到小腿缺血肌肉内。结果 58例患者术后跛行距离增加,冷、凉感觉得到改善。结论血管内超声消融联合自体骨髓干细胞移植治疗下肢动脉硬化性闭塞症是一种简单、有效的方法。Objective To investigate the efficacy of ultrasound ablation and autologous transplantation of bone marrow mononuclear cells in the treatment of arteriosclerosis obliterans. Methods A total of 56 patients with arteriosclerosis obliterans were treated with ultrasound ablation and autologous transplantation of bone marrow mononuclear cells. Through percutaneous approach or surgical approach the ultrasound ablation catheter was inserted into occluded arterial segments. After ablation performed, autologous bone marrow rnononuclear cells were directly injected into the skeletal muscles of the ischemic crura. Results No complications were found in this group. Postoperatively the skin turned warm in all legs. Conclusions Ultrasound ablation and autologous transplantation of bone marrow mononuclear cells is simple, safe and effective in the treatment of patients with arteriosclerosis obliterans.

关 键 词：动脉硬化 闭塞性 治疗 超声疗法 干细胞移植 治疗应用 

分 类 号：R543.5[医药卫生—心血管疾病]