难治性肾病综合征患者血凝学的研究  

Research of blood coagulation in refractory nephrotic syndrome

作　　者：魏连波[1] 粟德林[2] 叶任高[3] 刘素雁[4] 马军[5] 马志刚[1] 高云飞[1] 

机构地区：[1]第一军医大学南方医院中医内科,广东广州510515 [2]黑龙江中医药大学,黑龙江哈尔滨510040 [3]中山医科大学肾脏研究所,广东广州510515 [4]哈尔滨医科大学附属二院肾内科,黑龙江哈尔滨510086 [5]哈尔滨市第一医院血液病研究所,黑龙江哈尔滨510076

出　　处：《第一军医大学学报》2000年第4期370-372,共3页Journal of First Military Medical University

摘　　要：目的 探讨难治性肾病综合征（RNS）患者血凝学指标的变化。方法 31例RNS为实验组，另设31例正常对照。两组均检测第Ⅷ因子相关抗原（ⅧR:Ag）、纤维蛋白原（Fbg）、抗凝血酶Ⅲ（AT-Ⅲ）、纤溶酶原（Plg）、白陶土部分凝血活酶时间（APTT）、凝血酶原时间（PT）及血小板聚集试验（PAgT）的变化。结果：ⅧR:Ag、Fbg、PAgT与正常组比较显著增高，AT-Ⅲ、Plg与正常组比较显著降低，APTT时间显著缩短，PT与正常对照组比较无显著性差异。ⅧR:Ag、AT-Ⅲ与尿素氮（BUN）、血浆白蛋白（A1b）呈正相关，Fbg、PAgT与A1b呈负相关。结论 RNS存在严重的高凝状态。Objective To discuss the changes of coagulation index in patients with refractory nephrotic syndrome (RNS). Methods 62 cases of RNS was divided into treatment group and normal group. To examine the levels of factor Ⅷ-related antigen (ⅧR:Ag), fibrinogen (Fbg), antithrombin III (AT-III), plasminogen (Plg), activated partial thrombolastin time (APTT), prothrombin time (PT), platelete aggregation test (PAgT). Results Compared with normal group, ⅧR:Ag, Fbg，PagT were increased obviously in RNS group; AT-Ⅲ,Plg was reduced obviously. The time of APTT was shortened and PT showed no significant different compared with comtrol group. ⅧR:Ag and AT-Ⅲ had positive correlation with BUN and A1b, while Fbg、PAgT a negative correlation with BUN and A1b. Conclusion There is a serious hypercoagulability state condition in patients with RNS.

关 键 词：肾病综合征 因子Ⅷ 纤维蛋白 血凝学 

分 类 号：R692[医药卫生—泌尿科学]