聚醚砜中空纤维膜血浆分离器血浆分离功能与血液相容性的评价  

Evaluation of Performance and Blood Compatibility of Polyethersulfone Hollow Fiber Plasma Separator

作　　者：刘霆[1] 余喜讯[2] 赵长生[2] 卢忠平 程莉萍 孟文彤[1] 乐以伦[2] 

机构地区：[1]华西医科大学附属第一医院血液科,成都610041 [2]四川大学生物医学工程中心,成都610065

出　　处：《生物医学工程学杂志》2000年第3期249-254,共6页Journal of Biomedical Engineering

基　　金：国家"九五"攻关课题! ( 97-5 64 -0 1-0 5 )

摘　　要：对新型材料聚醚砜制作的中空纤维膜血浆分离器进行动物实验 ,评价了膜对血浆蛋白的分离功能及材料的血液相容性。分离过程中 ,实验动物状况良好 ,无溶血现象发生 ,膜对血浆总蛋白、白蛋白和球蛋白的筛分系数均在 95以上 ,约 6 0的血浆从全血中分离出来。白细胞、血小板和四种凝血因子在分离开始时都有不同程度地减少 ,但均在临床允许的范围内。In this study, we evaluated the performance and blood compatibility of polyethersulfone hollow fiber membrane plasma separator by animal experiment. Hemolysis did not occur under the usual conditions of plasma separation. The sieving coefficients of total protein, albumin and globulin were over 95%, and about 60% of total plasma were extracted from the whole blood. White blood cells, platelets, fibrinogen, and coagulation factors were decreased during the early stage of plasma separation and appeared to be within acceptable ranges for clinical use.

关 键 词：聚醚砜中空纤维膜 血浆分离器 血液相容性 

分 类 号：R457[医药卫生—治疗学]