病因模拟法建立小儿厌食症动物模型  

Establishment of model of juvenile rat with anorexia produced by simulating the cause of disease

作　　者：张月萍[1] 杜永平 汪受传[2] 史健[1] 汪静[1] 吴少华[1] 

机构地区：[1]第四军医大学西京医院儿科,西安710032 [2]南京中医药大学第一临床医学院儿科疾病实验室

出　　处：《西安医科大学学报》2000年第4期358-359,380,共3页Journal of Xi'an Medical University(Chinese)

基　　金：国家自然科学基金! ( No:3 9670 896)

摘　　要：采用病因模拟法建立小儿厌食症动物模型。方法　用鱼松、奶粉、黄豆粉、白糖、鸡蛋等市售食品按比例配制特制饲料喂养幼龄大鼠建立动物模型 ,观察对大鼠摄食量、体重及下丘脑和血浆八肽胆囊收缩素 ( CCK- 8)浓度的影响 ,同时对特制饲料与常规鼠饲料的主要营养成分进行对比。结果　模型大鼠日摄食量明显低于对照组 ,体重增长缓慢 ,下丘脑和血浆八肽胆囊收缩素水平显著升高。特制饲料多种矿物质及多种维生素含量低下。结论　该模型符合小儿厌食症的自然病因和主要临床表现 ,状态稳定 。Objective To establish a model of juvenile rat with anorexia by simulating the cause of disease.Methods Special forage and routine forage were used to feed the juvenile rats in order to observe the effect on appetite,weight,CCK 8 concentration in hypothalamus and plasma, and then compared the relative nutrients.Results The model rats,as compared with the control group,had reduced amount of food intake, reduced body weight and increased CCK 8 concentration in hypothalamus and plasma.The special forage contained less minerals and vitamins,which corresponded with the main clinical manifestations and main causes of infantile anorexia.Conclusion The results show that the model which is established in this experiment is reliable and successful.

关 键 词：厌食 动物模型 CCK-8 儿童 病因模拟法 

分 类 号：R272.402[医药卫生—中医儿科学]