噻托溴铵治疗激素依赖性哮喘疗效观察  

Effect Observation of Treating Steroid Dependent Asthma by Tiotropium Bromide

作　　者：陈颖丰[1] 

机构地区：[1]广东省揭阳市人民医院呼吸内科,广东揭阳522000

出　　处：《中外医疗》2013年第14期48-49,共2页China & Foreign Medical Treatment

摘　　要：目的探讨噻托溴铵(18ug)对支气管哮喘患者中激素依赖性者的临床疗效。方法将符合支气管哮喘诊断及激素依赖性哮喘临床表现患者40例分为研究组和对照组,每组20例,对照组给予舒利迭(50/500ug)吸入、孟鲁司特口服、茶碱缓释片口服,研究组给予噻托溴铵(18ug)吸入、舒利迭(50/250ug)吸入、孟鲁司特口服、茶碱缓释片口服,每4周随访1次,疗程8周。结果两组比较研究组肺功能及ACT评分(哮喘控制测试评分)改善情况优于对照组,差异有统计学意义(P<0.01)。结论使用噻托溴铵治疗激素依赖性哮喘,有效地控制哮喘症状、降低ICS吸入量。Objective To discuss the clinical treatment effect of trcotiog Steroid Depeodent Asthma （SDA）by Tiotropium bromide （18ug）. Methods A total of 40 patients with Steroid Dependent Asthma were divided into the study group and the control group randomly,with 20 cases each. The control group only treated with seretide 50/500ug inhalation twice daily in combination with Montelukast and Theophylline Sustained-Release Tablets orally, The treatment group treated with inhaled tiotropium bromide 18ug once a day,seretide 50/500ug inhalation twice daily in combination with Montelukast and Theophylline Sustained-Release Tablets orally~ Patients were visited once every 4 weeks and the treatment course is 8 weeks. Results Lung function and the asthma con- trol test （act） scores were improved in the study group compared with the control one.There was significant difference between two groups（P〈O.01 ）. Conclusions Treating Steroid Dependent Asthma（SDA）by Tiotropium could control the symptom of asthma effec- tively and could reduce ICS intake.

关 键 词：抗胆碱药物 噻托溴铵(18ug) 支气管哮喘 激素依赖性哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]