紫花地丁化学成分与药理活性研究新进展  

Study advancement about chemical composition and pharmacological action of Viola yedoensis

作　　者：李永生[1] 何希瑞[1] 杨燕 张春玲[1] 常育[1] 何睿[1] 

机构地区：[1]西安交通大学医学院附属红会医院药剂科,710054 [2]中航工业西安医院药剂科

出　　处：《环球中医药》2013年第4期313-318,共6页Global Traditional Chinese Medicine

摘　　要：紫花地丁(Viola yedoensis)为堇菜科堇菜属植物,含有多种化学成分,并具有较强的药理活性和较大的利用价值。目前,已经从紫花地丁药用植物中分离得到70多种化合物,包括黄酮类化合物27个、香豆素类化合物16个、有机酸类化合物16个和其他类化合物13个。体内外实验研究表明,紫花地丁的粗提取物具有广泛的药理作用,尤其是在抗炎、抑菌、抗病毒和抗肿瘤方面效果显著。紫花地丁的活性研究多限于粗提取物的抗炎、抑菌和抗病毒研究,作用机理研究不够深入,今后应加强其有效部位、活性单体和作用机理方面的研究,从而扩大该药材的开发利用。Viola yedoensis, with a variety of chemical constituents, belongs to the family Violace- ae, and has a strong pharmacological activity and greater use of value. Up to now, more than 70 compounds have been isolated and identified, including 27 flavonoids, 16 coumarins, 16 organic acids and 13 others compounds. In vivo and in vitro studies indicated that rude extracts and several monomer compounds from Viola yedoensis possessed wide pharmacological actions, especially in antiinflammatory, antibacterial activity, anti-viruses and anti-tumor, etc. The pharmacological studies were mostly confined to the anti-inflammatory, antibacterial and antiviral activity of the crude extract, and the research on mechanisms are not deep enough. In the future, the studies should be focus on the active site, the active monomer and the mechanism of actions, so that we can provide basis and references for the development and utilization of the plant.

关 键 词：紫花地丁 黄酮 香豆素 抗病毒 

分 类 号：R285[医药卫生—中药学]