米非司酮联合甲氨蝶岭保守治疗输卵管妊娠的研究  

Effects of Mifepristone Combined with Methotrexate in Conservative Treatment of Tubal Pregnancy Study

作　　者：张琼[1] 

机构地区：[1]云南省曲靖市第一人民医院妇产科,云南曲靖655000

出　　处：《中国医药指南》2013年第9期32-33,共2页Guide of China Medicine

摘　　要：目的探讨研究米非司酮联合甲氨蝶岭保守治疗输卵管妊娠的应用价值。方法对本院2010年5月至2012年5月诊断为非破裂性输卵管妊娠的86例患者作为研究对象,将86例患者分为两组,A组45例,治疗方案采用甲氨蝶岭50mg/m2,单次肌内注射,在肌内注射的同时,顿服米非司酮300mg,B组41例,治疗方案单纯采用甲氨蝶岭50mg/m2,单次肌内注射,分析并比较两组之间临床治疗效果。结果 A组的住院时间、血β-HCH降至正常时间均短于B组,两组比较差异有统计学意义(P<0.05);A组患者治愈率高于B组,两组比较差异有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论米非司酮联合甲氨蝶岭保守治疗早期输卵管妊娠的临床效果优于甲氨蝶岭单纯治疗,值得在临床推广。Objective To explore study on mifepristone combined with methotrexate in conservative treatment of tubal pregnancy value.Method In our hospital from 2010.5~2012.5 for diagnosis of non-ruptured tubal pregnancy 86 cases as the object of study,86 patients were divided into two groups,45 cases in group A,therapeutic regimens using MTX 50 mg/m2,single intramuscular injection,intramuscular injection at the same time,Taking mifepristone 300 mg,B group of 41 patients,treatment with MTX 50 mg/m2,a single intramuscular injection,analyzed and compared between the two groups of clinical therapeutic effect.Result In A group,duration of hospitalization,blood β-HCH to normal time was shorter than that in group B,there was significant difference between two groups（P0.05）;groupApatients cure rate higher than that of B group,there was significant difference between two groups（P0.05）;two groups of patients the incidence of adverse reactions to compare difference not to have statistical significance（P0.05）.Conclusion Mifepristone combined with methotrexate in conservative treatment of early tubal pregnancy with better clinical results than methotrexate alone for treatment,it is worth promoting in clinical.

关 键 词：米非司酮 甲氨蝶岭 早期输卵管妊娠 治疗 

分 类 号：R714.221[医药卫生—妇产科学]