超敏C反应蛋白测定在慢性阻塞性肺疾病急性加重期的临床意义  

Clinical Significance of Detecting High-sensitivity C-Reactive Protein in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：王永[1] 吕高荣[1] 

机构地区：[1]江苏省新沂市铁路医院呼吸内科,221400

出　　处：《中华全科医学》2013年第6期881-883,共3页Chinese Journal of General Practice

摘　　要：目的观察血清中超敏C反应蛋白(hs-CPR)在慢性阻塞性肺疾病急性加重期(AECOPD)患者治疗中的应用价值。方法观察组与对照组各90例,采空腹肘静脉血3 ml,应用免疫散射比浊法测定两组患者血清中hs-CPR的浓度。结果观察组hs-CRP含量明显高于对照组,观察组治疗后hs-CRP含量均明显下降。观察组hs-CRP随着临床分级越重浓度越高,各期之间对比差异均有统计学意义(P<0.01)。结论血清中hs-CRP是反映AECOPD患者肺部感染的敏感指标,是用来观察监测AEC0PD治疗效果最良好的指标之一,对于评价AECOPD患者病情严重程度及预后有较好的评估价值,值得在临床上推广应用。Objective To Discuss actions of serum high-sensitivity C-reactive protein （hs-CPR） level in the treatment of pa- tients with an acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods The fasting blood samples from were collected from 90 patients with an acute exacerbation of COPD （ observation group） and 90 patients without cardiovascular or pulmonary diseases （control group） before and after treatment. The hs-CPR level in both groups was measured by an immunon- ephelometric assay. Results The hs-CPR level of the observation group before treatment was obviously higher than that of the control group, and was significantly decreased after the treatment. The concentration of hs-CRP in the observation group paral- leled to the clinical classification, and the differences between these phases were-statistically significant （P 〈 0.01 ）. Conclu- sion The serum hs-CRP is a sensitive marker indicating the pulmonary infection of COPD patients, and is one of the best mark- ers to monitor the therapeutic effect in patients with an acute exacerbation of COPD. hs-CRP is important in evaluating the severi- ty and prognosis of patients with an acute exacerbation of COPD, and can be widely used in clinic.

关 键 词：超敏C反应蛋白 慢性阻塞性肺疾病 急性加重期 临床意义 

分 类 号：R563.9[医药卫生—呼吸系统] R446.11[医药卫生—内科学]