分娩镇痛后产妇血清IL-6、IL-8、IL-10的变化  

Effect of analgesia with continued epidural block on the serum IL-6,IL-8 and IL-10 in parturients

作　　者：修玉芳[1] 黄东林[1] 王颖[1] 肖龙[1] 

机构地区：[1]辽宁省大连市妇产医院,116033

出　　处：《中国妇幼保健》2013年第16期2553-2554,共2页Maternal and Child Health Care of China

摘　　要：目的:观察罗哌卡因连续硬膜外阻滞进行分娩镇痛对产妇血清中IL-6、IL-8、IL-10的影响。方法:将200例产妇随机分为观察组和对照组各100例。观察组在宫口开至2～3 cm时,开始采用连续硬膜外阻滞进行分娩镇痛;对照组按产科常规处理。观察两组产妇分娩镇痛前30 min、分娩镇痛后2 h、分娩后24 h、48 h和72 h等5个时点的IL-6、IL-8、IL-10水平的变化。结果:两组产妇分娩镇痛后血清IL-6、IL-8、IL-10水平与分娩镇痛前比较均有升高(P<0.01),且多在分娩后24 h达峰值,对照组较观察组升高更为明显(P<0.05)。结论:罗哌卡因连续硬膜外阻滞进行分娩镇痛可有效降低产妇分娩后炎性应激反应。Objective： To observe the effect of labor analgesia with continued epidural block on the serum IL - 6, IL - 8 and IL - 10 in parturients. Methods： Two hundreds of labor women were divided into two groups with 100 cases each group. One hundred parturi- ents were selected as labor analgesia group （ group I ） and the others were as nature delivery group without analgesia （ group ]I ） . Analgesia was used when utero - cervical was opened to 2 ~ 3 cm. The levels of serum IL - 6, IL - 8 and IL - 10 were observed at five time points ： be- fore labor analgesia, at 2 h after the labor analgesia, at 24 , 48 , 72 h after delivery. Results ： The levels of serum IL - 6, IL - 8 and IL - 10 were increased significantly after labor analgesia, reached at peak values at 24 h （P 〈 0. 05）, and then gradually declined but still higher than the baseline values. The serum IL-6, IL-8 and IL- 10 were significantly higher at 2 and 24 h in group 11 than those in group I （ P 〈 0. 05 ） . Conclusion ： Labor analgesia with continued epidural block is safe and effective. Epidural analgesia can reduce the level of se- rum IL- 6, IL- 8 and IL- 10 and inflammatory response during delivery.

关 键 词：分娩镇痛 连续硬膜外阻滞 IL-6 IL-8 IL-10 

分 类 号：R714.3[医药卫生—妇产科学]