Uu感染及孕妇外周血中IL-8、IL-10水平变化与反复自然流产的相关性  

The relationship between Uu infections,IL-8,IL-10 level changes in peripheral blood and recurrent spontaneous abortion

作　　者：王振荣[1] 刘娜[1] 高庆双[1] 李宜学[2] 王丽[2] 王丽荣 

机构地区：[1]河北省唐山市妇幼保健院检验科,063000 [2]河北省唐山市妇幼保健院生殖遗传科 [3]河北省滦县人民医院妇产科

出　　处：《中国妇幼保健》2013年第16期2602-2604,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨反复自然流产患者感染解脲脲原体(Uu)与外周血IL-8、IL-10水平变化的关系。方法:选择98例反复自然流产患者(观察组)和正常同期匹配妊娠者98例(对照组),采用酶联免疫吸附试验对两组外周血IL-8、IL-10水平进行测定,两组分别采集宫颈分泌物进行支原体培养与鉴定。结果:反复自然流产组血IL-8水平显著高于对照组,而IL-10水平显著低于对照组,差异均有统计学意义(P<0.05);Uu感染阳性率显著高于对照组,差异有统计学意义(P<0.05)。结论:Uu感染可引起孕妇血清IL-8水平增高、IL-10水平降低;IL-8水平过高、IL-10水平过低可增加反复自然流产的风险。Objective： To explore the relationship between infection Ureaplasma urealyticum （Uu） infections and IL -8, IL - 10 level changes in peripheral blood and recurrent spontaneous abortion . Methods： 98 cases of recurrent spontaneous abortion （ observation group） and 98 cases of normal pregnancy （ control group） at the same time were selected The level of IL - 8, IL - 10 were investigated in peripheral plasma by ELISA. The genital tract secretion was collected for mycoplasma training and drug susceptibility test appraisal. Results： The level of IL - 8 and the Uu infection positive rate were significantly higher in observation group than those of control group, the differences were statistically significant （P 〈 0.05 ） ; The level of IL - 10 was significantly lower in observation group than that of control group, the difference was statistically significant （P 〈 0.05 ） . Conclusion： Uu infection can cause IL -8 increasing and IL - 10 decreasing in pregnant women, which increases the risk of recurrent spontaneous abortion.

关 键 词：解脲脲原体 IL-8 IL-10 反复自然流产 

分 类 号：R714.21[医药卫生—妇产科学]