药源性睡眠障碍58例文献分析  

Literatural Analysis of 58 Cases of Drug-induced Somnipathy

作　　者：崔沛苓 陈丽芳[2] 

机构地区：[1]天津市天和医院,天津300070 [2]天津市海河医院,天津300350

出　　处：《中国药房》2013年第22期2086-2087,共2页China Pharmacy

摘　　要：目的:探讨引起药源性睡眠障碍的药品特点及一般规律。方法:对2001年1月至2012年11月国内文献报道的药源性睡眠障碍58例进行统计、分析。结果:药源性睡眠障碍涉及10大类30种药品,以抗菌药物引发率最高(占44.83%),其次为消化系统药(占13.79%)。静脉给药16例,11例睡眠障碍出现在给药后当晚,5例在给药后2～3d;口服给药38例,均出现在给药后2～3d;皮下注射重组人粒细胞集落刺激因子4例,均出现在给药后2～4d。结论:在应用上述药品时应注意观察药源性睡眠障碍的发生。OBJECTIVE： To discuss the characteristics and general features of drug-induced somnipathy. METHODS： 58 drug-induced somnipathy cases reported in domestic medical journals from Jan. 2001 to Nov. 2012 were statistically analyzed. RE- SULTS： The drug-induced somnipathy cases involved totally 30 agents in 10 drug categories, with anti-infective agents accounting for the highest proportion （44.83%）, followed by the digestive system drugs （13.79%）. There were 16 cases of intravenous ad- ministration, 11 cases suffered from somnipathy after medication that night, and 5 cases appeared 2-3 days after medication. There were 38 cases of oral administration, and symptom appeared 2-3 days after medication. 4 cases was given hypodermic injection of recombinant human granulocyte-colony stimulating factor, and somnipathy appeared 2-4 days after medication. CONCLUSIONS： The occurrence of drug-induced somnipathy ought to be observed when using above-discussed drugs.

关 键 词：药品不良反应 药源性睡眠障碍 文献分析 

分 类 号：R969.3[医药卫生—药理学]