真菌甲硫氨酸生物合成途径研究进展  

Advances in methionine biosynthesis in fungi

作　　者：付静[1] 尹燕妮[1] 马忠华[1] 

机构地区：[1]浙江大学生物技术研究所,杭州310058

出　　处：《植物病理学报》2013年第3期225-231,共7页Acta Phytopathologica Sinica

基　　金：国家自然科学基金资助项目(30900930)

摘　　要：甲硫氨酸是蛋白质的重要组分,同时还可通过生成S-腺苷甲硫氨酸(SAM)调控细胞内多种生理过程。本文根据酿酒酵母、粗糙脉孢菌和构巢曲霉3种模式真菌中甲硫氨酸生物合成的最新研究进展,勾画出真菌的甲硫氨酸合成途径,综述了该途径中关键酶的生物学功能,探讨了该途径的调控机制,为病原真菌甲硫氨酸合成的研究提供理论基础,同时为新杀菌剂的研发提供新思路。The sulfur-containing amino acid, methionine, is not only a key component of protein, but also displays many essential functions in cellular metabolism through its main derivative S-adenosylmethionine （SAM）. According to the researches on methionine biosynthesis in Saccharomyces cerevisiae, Neurospora crassa and Aspergillus nidulans, we sketched the methionine biosynthesis pathway in fungi, and summarized biological functions of key enzymes and regulation mechanism of the pathway. Information from this review may make a contribution to further research of methionine biosynthesis in plant pathogenic fungi and to the development of new fungicides.

关 键 词：真菌 甲硫氨酸合成途径 关键酶 调控机制 

分 类 号：S432.1[农业科学—植物病理学]