脑钠肽和超敏C反应蛋白检测与慢性心力衰竭预后的相关性  

Correlation Between Levels of Brain Natriuretic Peptide and High-Sensitivity C-Reactive Protein Detection and Prognosis of Chronic Heart Failure

作　　者：黄炎[1] 陈峻[1] 贾珉[1] 陈杰[1] 张惜[1] 

机构地区：[1]武汉市第一医院检验科,武汉430022

出　　处：《血栓与止血学》2013年第3期124-125,128,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)联合检测在慢性心力衰竭(CHF)患者长期预后评估中的临床价值。方法检测武汉市第一医院2011年9月至2012年9月住院的慢性心力衰竭患者126例血浆BNP、hs-CRP水平,并与52例健康体检者对比,出院后随访1年,观察CHF患者心脏事件的发生情况。结果 CHF患者BNP、hs-CRP水平明显增高,CHF患者BNP、hs-CRP水平与对照组比较均有统计学意义。不同心功能分级患者之间BNP、hs-CRP水平随NYHA分级的增高而增高,且都高于对照组。结论血浆BNP、hs-CRP水平监测对CHF患者的预后评估具有重要的临床意义。Objective To evaluate the long-term clinical value of brain natriuretic peptide （BNP）and high- sensitivity C- reactive protein （ hs- CRP） in patients with chronic heart failure （CHF）. Methods The plasma BNP and hs-CRP levels in 126 CHF patients were measured and compared with 52 subjects as normal control. These patients were followed up for a mean period of 1 year to observe the occurrence of cardiac events. Results BNP and hs-CRP levels were significantly higher in patients with CHF. Compared with control group, BNP and hs-CRP levels in CHF patients change significantly. Besides, for CHF patients, with the NYNA grades raises, BNP and hs-CRP levels increase progressively, During follow-up period, CHF patients with cardiac events have higher BNP and hs-CRP levels than patients without cardiac events. Conclusion Monitoring of plasma BNP levels has important clinical significance to judge the prognosis in patients with CHF.

关 键 词：脑钠肽 超敏C反应蛋白 慢性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]