壳聚糖接枝聚乙烯亚胺的合成与表征  

Synthesis and characterization of chitosan graft polyethyleneimine

作　　者：吕滋建[1] 李爱香[1] 李秋红[1] 韩冰[1] 张伟[1] 

机构地区：[1]山东理工大学材料科学与工程学院,山东淄博255091

出　　处：《山东理工大学学报（自然科学版）》2013年第1期1-4,共4页Journal of Shandong University of Technology:Natural Science Edition

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(2010BSB01009);山东省自然科学基金资助项目(ZR2012BQ008);山东理工大学青年教师发展支持计划

摘　　要：用一种简单有效的方法合成了稳定的壳聚糖接枝聚乙烯亚胺接枝共聚物(CHI-g-PEI).首先利用高碘酸盐对壳聚糖进行氧化,合成含醛基的壳聚糖;然后利用PEI上的氨基与醛基的席夫碱反应进行接枝;最后用硼氢化钠(NaBH4)还原亚胺,得到稳定的接枝共聚物CHI-g-PEI.研究了反应时间和反应温度对氧化壳聚糖产率的影响,以及PEI用量对接枝率的影响.产物和中间体用红外光谱(IR)、核磁谱图(1 H-NMR)和紫外可见光谱(UV-Vis)等进行了表征.Chitosan graft polyetheneimine copolymers （CHI-g-PEI） were synthesized by a facile method. Firstly, CHI containing formyl group was prepared through oxidation reaction of CHI by periodate potassium. Then graft reaction was carried out between amino of PEI and formyl groups of CHI, and stable graft copolymer of CHI-g-PEI was obtained by reduction reaction by sodium borohydride （NaBH4）. The effects of reaction time and temperature on the yield of oxida-tion CHI and the effect of PEI amount on grafting yield were studied. The product and its precur-sors were characterized by IR, ^1H-NMR, and UV-Vis.

关 键 词：壳聚糖 聚乙烯亚胺 接枝聚合物 基因载体 

分 类 号：O631[理学—高分子化学]