低浓度混苯暴露与精液质量下降及早早孕丢失的关系  

Studies on relationship between exposure to low concentration of mixed benzene a nd lower quality of semen and very early fetal loss

作　　者：王守林[1] 陈海燕[1] 王心如[1] 宋玲[1] 张绮[1] 杜冰[2] 曹晋柱[2] 王顶贤 施爱民 徐希平[4] 

机构地区：[1]南京医科大学应用毒理研究所,210029 [2]扬子石油化工公司医院职业病防治所 [3]仪征化纤集团公司医院预防保健中心 [4]南京医科大学哈佛大学公共卫生学院生态遗传与临床流行病学合作研究中心

出　　处：《中华预防医学杂志》2000年第5期271-273,共3页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金!资助 (396 40 0 0 6 )

摘　　要：目的　研究低浓度混苯暴露对职业人群精液质量和早早孕丢失的影响。方法　选择混苯作业工人 12 6人、无混苯作业对照者 6 0人 ,进行生产环境监测和生物学监测 ;按混苯接触情况 ,选择暴露组男工 70人、内对照组男工 90人、外对照组男工 132人 ,进行精液质量分析 ;选择暴露组女工42人、内对照组女工 49人、外对照组女工 118人 ,进行尿液人绒毛膜促性腺激素的检测。结果　石化企业混苯暴露以低浓度苯 (0 7～ 2 7 0mg/m3)为主 ,工人尿液反 ,反 粘糠酸与空气苯浓度呈高度相关性 ;暴露组和内对照组精子的活动度 (1 97± 0 6 3和 1 97± 0 6 9)与活动精子百分率 (0 5 5± 0 16和0 5 5± 0 17)均显著低于外对照组 (2 5 6± 0 6 1和 0 6 0± 0 13) ,但其异常率显著高于外对照组 ,且暴露组精液综合异常率 (85 71% )显著高于内对照组 (70 0 0 % )和外对照组 (76 5 1% ) ;暴露组和内对照组女工早早孕丢失发生率及其周期发生率均高于外对照组 ,且二组女工周期发生率 (10 42 %、9 6 0 % )显著高于外对照组女工 (5 0 9% )。结论　低浓度混苯暴露可能与职业人群精液质量下降及早早孕丢失有关 ,尿液反 ,反 粘糠酸和人绒毛膜促性腺激素可分别作为接触性和效应性生物标志物。Objective To study the effects of exposure to low concentration of mixed benzene on their semen quality and very early fetal loss (VEFL) in the occupational population. Methods Environmental monitoring and biological monito ring were conducted in 126 employees exposed to mixed benzene and 60 unexposed o nes selected from a large petrochemical corporation and a large chemical fiber c orporation. Quality of semen in 70 male workers in the exposed group and 90 mal e internal controls and 132 male external controls were analyzed, and urinary β -human chorionic gonadotropin （β-hCG） was determined for 42 female exposed workers and 49 female internal controls and 118 external controls. Results ① Expos ure to mixed benzene mainly existed in low concentrations （0 7～27 0 mg/m 3 ）in t he petrochemical corporation, and urine concentration of t,t-MA in the workers c orrelated significantly to benzene concentration in ambient air of the workshops （ r =0 64, P =0 03）. ② The sperm progression and motility in the expo sed （1 97±0 63 and 0 55±0 16） and the internal control （1 97±0 69 an d 0 55±0 17） groups were significantly ( P< 0 05) lower than those in the external control group （2 56±0 61 and 0 60±0 13）, however, the sper m abnormality rates in the exposed and internal control groups were significantl y ( P< 0 01) higher than those in the external control group, and the sum mary abnormality rate of sperm in the exposed group （85 71%） was higher than that in the internal （70 00%）and external control（76 51%）groups （ P< 0 05）. ③ The incidence rates of the VEFL in female workers and the cyclic o ccurrence of VEFL both in the exposed and internal control groups （10 42％ and 9 60％）were higher than those in the external control group （5 09％）, with statistical significance（ P< 0 05）. Conclusions Exposure to low concentration of mixed benzene maybe correlated with the declined quality of semen and VEFL in occupational worke

关 键 词：职业暴露 精液质量 早早孕丢失 低浓度混苯 

分 类 号：R135.12[医药卫生—劳动卫生] R711.602[医药卫生—公共卫生与预防医学]