抗孕唑对妊娠大鼠子宫蜕膜、前列腺素含量和宫缩的影响  

EFFECTS OF DL111-IT ON DECIDUA, PGs CONTENTS AND UTERINE CONTRACTILITY IN PREGNANT RATS

作　　者：杨波[1] 曹霖[1] 顾芝萍 

机构地区：[1]中国科学院上海药物研究所,上海200031

出　　处：《药学学报》2000年第9期641-644,共4页Acta Pharmaceutica Sinica

基　　金：上海市自然科学基金!(97ZD14 0 2 7)

摘　　要：目的　研究抗孕唑对妊娠大鼠子宫蜕膜组织形态 ,PGF2α和PGE2 含量及对离体大鼠子宫收缩幅度的影响。方法　用HE染色 ,放射免疫法和离体子宫收缩记录等方法。结果　抗孕唑使妊娠大鼠子宫蜕膜细胞受损、剥离 ,并使子宫和血清中PGE2 和PGF2α的含量升高 ;对离体妊娠大鼠子宫有收缩作用 ,其效价为米索前列醇的 0 6倍。结论　抗孕唑损伤蜕膜细胞 ,刺激释放前列腺素 。AIM To observe the effects of DL111 IT on decidual cells, content of PGE 2 and PGF 2α , and uterine contractibility of pregnant rats. METHODS HE stain, radioimmunoassay and uterine contractility in vitro were used to estimate histologitic changes in decidual cells, PGE 2 and PGF 2α concentration in uterus and serum and the uterine contrability of pregnant rats, respectively. RESULTS After im DL111 IT ×5 d, the PGE 2 and PGF 2α contents in uterus of pregnant rats increased 118 2% and 213 7%, respectively, and those in serum were increased 74 3% and 227 7%, respectively. Edema, degeneration and solvate at decidual cells with indefinite nuclei were observed in pregnant rats treated with DL111 IT for 3～5 days. DL111 IT strengthened the uterine contraction of pregnant rats and the uterine response to oxytocin and misoprostol in vitro . CONCLUSION DL111 IT damaged the decidual cells, incresed the concentrations of PGE 2 and PGF 2α , and strengthened the contractibility of pregnant uterine.

关 键 词：抗孕唑 前列腺素 子宫蜕膜 子宫收缩 人工流产 

分 类 号：R169.42[医药卫生—公共卫生与预防医学] R984