二甲双胍治疗2型糖尿病患者中加用利拉鲁肽的临床效果观察  

Effects of liraglutide on glycemic gontrol in metformin-treated patients with type 2 diabetes mellitus

作　　者：李洁[1] 王扬天[1] 许一新[1] 陈晔[1] 王坚[1] 彭丽[1] 

机构地区：[1]南京军区南京总医院内分泌科,210002

出　　处：《中国综合临床》2013年第6期612-614,共3页Clinical Medicine of China

摘　　要：目的 探讨二甲双胍治疗的2型糖尿病（T2DM）患者中加用利拉鲁肽的效果。方法20例T2DM患者口服最大耐受剂量二甲双胍至少2个月，加用利拉鲁肽0．6mg，治疗1周后改为1．2mg，治疗3个月。观察治疗前后血糖、糖化血红蛋白、胰岛功能、血脂、体质量的差异。结果治疗前后比较，空腹血糖[（8．9±1．4）mmol／L与（6．9土1．0）mmol／L，t=5．951，P〈0．01]，餐后血糖[（14．4±1．5）mmolfL与（10．4±1．4）mmol／L，t=8．878，P〈0．01]，糖化血红蛋白[（8．7±1．3）％与（7．6±1．1）％，t=4．860，P〈0．01]、空腹c肽[（1．7±0．6）mg／L与（2．9±1．1）mg／L，t=5．752，P〈0．01]、餐后2hC肽[（5．0±2．3）mg／L与（10．2±3．5）mg／L，t=5．667，P〈0．01]，差异均有统计学意义，以及血脂和体质量水平均与治疗前相比差异有统计学意义（P均〈0．01）。结论利拉鲁肽可持续有效地控制T2DM患者的血糖，减轻体质量，改善血脂水平和胰岛B细胞功能，且发生低血糖的风险低。Objective To investigate the therapeutic effect of liraglutide on glycemic control in metformin-treated patients with type 2 diabetes mellitus （T2DM）. Methods Twenty patients with T2DM by maximum tolerated dose of metformin in this study. For at least 3 months, participants were treated by addingliraglutide. After 1 week, the dosage of liraglutide was increased to 1.2 mg for 3 months from 0. 6 mg. Patients＇ blood glucose, glycosylated hemoglobin （HbAlc）, islet function, blood lipid and body weight were observed. Results Compared with before treatment, there were significant change of fasting blood glucose （ （8.9 ±1.4） mmol/L vs. （6. 9 ± 1.0） mmol/L,t = 5. 951 ,P 〈 0. 01 ） ,postprandial blood glucose （ （ 14. 4 ± 1.5） mmol/L vs. （10.4 ±1.4） mmol/L,t =8. 878,P〈0.01））,HbAle （（8.7 ±1.3）% vs. （7.6 ±1.1）% , t = 4. 860,P 〈 0.01 ）, fasting C peptide （ （ 1.7 ± 0. 6） mg/L vs. （ 2. 9 ± 1.1 ） mg/L, t = 5. 752, P 〈 0.01 ） and postprandial 2 h C peptide （ （ 5.0 ± 2. 3 ） mg/L vs. （ 10. 2 ± 3.5 ） mg/L, t = 5. 667, P 〈 0. 01 ） after treatment. Significant change of blood liquid and body weight were also observed after treatment than before treatment （P 〈 0.01 ）. Conclusion Liraglutide treatment resulted in persistent better glyeaemic control, weight reduction, improvements of blood lipid and function of pancreatic island successfully. Liraglutide was also associated with low risk of hypoglycemic and should be chosen by patients with T2DM.

关 键 词：2型糖尿病 二甲双胍 利拉鲁肽 血糖 

分 类 号：R587.1[医药卫生—内分泌]