氟砷染毒对大鼠子代微量元素的影响  

Effect of fluoride arsenic exposure on the trace elements in serum of rat's offspring

作　　者：张晨[1] 刘继文[1] 凌冰[1] 王国荃[1] 肖碧玉[1] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2000年第3期195-197,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金资助项目!(39560075)

摘　　要：目的 :揭示氟砷共存时对子代微量元素的影响。 方法 :采用两代一窝繁殖实验的方法 ,测定亲代大鼠暴露于氟砷后其子代血液中微量元素的水平。 结果 :随着氟砷暴露剂量的增加血清铜 (Cu)、锌 (Zn)、硒 (Se)和锰(Mn)浓度随之降低 ,铁 (Fe)变化不明显 ;停止氟砷暴露 8周后 Cu、Zn、Se和 Mn浓度均明显增加。结论Objective: In order to explore the effect of the fluoride arsenic exposure on the trace elements. Methods: The contents of trace elements in serum of rat's offspring were determined with the method of two generation one nest reproductive test. Results: The contents of cupper(Cu)、zinc(Zn)、selenium(Se) and manganese(Mn) in the serum were decreased when exposed doses increased, but the changes of iron(Fe) were not significant. After stopping the exposure for 8 weeks, the Cu、Zn、Se and Mn increased distinctly. Conclusion: Fluoride arsenic exposure can affect the levels of trace lements in serum of rat's offspring.

关 键 词：氟砷染毒 血清 微量元素 大鼠子代 

分 类 号：R995[医药卫生—毒理学] Q851[医药卫生—药学]