赤土茯苓苷对大鼠心肌缺血的保护作用  

Protective Effects of Smiglabrin in Acute Myocardial Infarcted rats by ligation of Left Coronary Artery

作　　者：邵春红[1] 新华 周承明 张克锦 

机构地区：[1]新疆医科大学药学院药理教研室,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2000年第3期205-207,共3页Journal of Xinjiang Medical University

摘　　要：目的 :研究赤土茯苓苷 (Smiglabrin,Smi)对大鼠心肌缺血的保护作用。 方法 :采用结扎冠脉造成大鼠心肌缺血的模型 ,测量大鼠心肌梗塞面积、心电图 (ECG) S- T段抬高幅度 ,测定心肌组织中 SOD、CPK、MDA和FFA的活性和含量。 结果 :结扎冠脉后 ,心肌中 SOD、CPK活性降低 ,MDA、FFA含量升高 ,心电图表现为 S- T段升高 ,预先给予大白鼠大剂量 Sm i10 0 m g/ kg和小剂量 Smi5 0 m g/ kg,连续 7d腹腔注射 ,能明显改善缺血心电图 ,显著缩小心肌梗塞面积 ,心肌组织中 SOD和 CPK活力提高 ,MDA和 FFA含量降低。 结论 :Smi可能通过提高心肌中 SOD和 CPK活力 ,抑制 MDA和Objective: The aim of the present study was to investigate protective effects of Smiglabrin (Smi) in acute myocardial infarction rats. Methods: Myocardial ischemia model was made ligating the left coronary artery of rats. The area of infarction and S T segment in ECG were observed, SOD and CPK activities, MDA and FFA contents were measured. Results: After the left coronary artery of rat was ligated, the activities of SOD and CPK were decreased, the concentrations of MDA and FFA were increased, S T segment in ECG was elevated, But if rats were administrated before experiment by Smi 50 mg/kg. d=7, 100 mg/kg. d=7,ip the amplitude of S T segment elevation was decreased, the area of infarction was reduced, the activities of SOD and CPK were increased, the concentrations of MDA and FFA were decreased. Conclusions: Smi may enhance the SOD and CPK activities, inhibite the MDA and FFA formation, to protect the ischemia myocardium by ligating the left coronary artery.

关 键 词：赤土茯苓苷 心肌缺血 大鼠 心肌保护 

分 类 号：R259.422[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]