增塑剂DEHP的发育和神经毒性研究进展  

Research advances in developmental and neurological toxicity of di(2-ethylhexyl) phthalate

作　　者：徐晓虹[1,2] 沈超[1] 周易[1] 秦泽旭[1] 梅成龙[1] 施剑[1] 

机构地区：[1]浙江师范大学化学与生命科学学院,浙江金华321004 [2]浙江师范大学生态研究所,浙江金华321004

出　　处：《浙江师范大学学报（自然科学版）》2013年第2期209-212,216,共5页Journal of Zhejiang Normal University:Natural Sciences

基　　金：国家自然科学基金资助项目(81172627);浙江省自然科学基金重点项目(Z2090955)

摘　　要：就DEHP(邻苯二甲酸二乙基己酯)的发育和神经毒性研究进展进行了概述.婴幼儿的DEHP摄入量远高于成年人,母体内的DEHP可能通过胎盘脂质及锌代谢影响胚胎发育,抑制多器官的生长发育并有致畸作用;胚胎期和新生期DEHP可能主要作用于睾丸间质细胞而影响生殖系统发育.DEHP不仅导致大鼠胚胎神经管发育畸形,还可通过血脑屏障影响脑内芳香化酶活性,抑制出生后海马脑区神经元密度,改变果蝇触角叶投射神经元突触前传递,这些作用有可能会改变动物成年后的神经行为.It was summarized the recent advances in research of developmental and neurological toxicity of DEHP.For the intake of DEHP in infants was much higher than that of adults,the materal DEHP affected embryonic development possibly through the placental lipid and zinc metabolism,and then inhibited the growth and development of organs.Embryonic and neonatal DEHP exposure might influence the reproductive system development mainly through the Leydig cells.DEHP not only led to embryonic neural tube malformations of rats but also affected aromatase activity of brain and inhibits neuronal density of hippocampus after birth through the blood-brain barrier.Pre-synaptic transmitter of antennal lobe projection neurons of Drosophila was found to be changed following DEHP treatment,which suggested that DEHP may influence the neurobehavioral development.

关 键 词：邻苯二甲酸二乙基己酯 发育毒性 神经毒性 环境雌激素 

分 类 号：R965[医药卫生—药理学]