新型截短侧耳素衍生物的体外抗菌活性研究  

Study on antibacterial activity of novel pleuromutilin derivatives in vitro

作　　者：赵喜[1] 王新杨[1] 黄金华[1] 凌勇[1] 

机构地区：[1]南通大学医学院药学实验室,江苏226001

出　　处：《交通医学》2013年第2期129-130,133,共3页Medical Journal of Communications

基　　金：南通大学医学院科研基金资助项目(2010/07)

摘　　要：目的:研究新型截短侧耳素衍生物对金黄色葡萄球菌(MSSA和MRSA)和表皮葡萄球菌(MSSE和MRSE)的体外抗菌活性。方法:采用微量肉汤稀释法测定其对MSSA、MRSA、MSSE和MRSE的最低抑菌浓度(MIC)。结果:新型截短侧耳素衍生物15,16a,16b对金黄色葡萄球菌和表皮葡萄球菌的MIC值均小于1μg·mL-1,抑菌效果明显优于阿莫西林。结论:新型截短侧耳素衍生物对金黄色葡萄球菌和表皮葡萄球菌具有很强的抑菌作用。Objective： To evaluate the antibacterial activity of novel pleuromutilin derivatives against staphylococcus aureus （MSSA and MRSA） and staphylococcus epidermids （MSSE and MRSE ） in vitro. Methods： The minimal inhibitory concentrations （MIC） to MSSA, MRSA, MSSE and MRSE were detected by broth dilution method. Results： The MIC of novel pleuromutilin derivatives 15, 16a, 16b against staphylococcus aureus and staphylococcus epidermids were less than 1μg.mL-1, and their antibacterial activity was obviously superior to amoxicillin. Conclusions： Novel pleuromutilin deriva- tives have strong antibacterial activity against staphylococcus aureus and staphylococcus epidermids.

关 键 词：截短侧耳素衍生物 耐甲氧西林金黄色葡萄球菌 甲氧西林敏感的金黄色葡萄球菌 耐甲氧西林表皮 葡萄球菌 甲氧西林敏感的表皮葡萄球菌 最低抑菌浓度 

分 类 号：R917[医药卫生—药物分析学]