头孢拉定缓释片的研制  

The study and preparation on the sustained-release tablets of cefradine

作　　者：王兰[1] 龚频[1] 张楠[1] 张瑞[1] 

机构地区：[1]陕西科技大学生命科学与工程学院,陕西西安710021

出　　处：《陕西科技大学学报（自然科学版）》2013年第3期93-96,101,共5页Journal of Shaanxi University of Science & Technology

基　　金：西安市未央区科技局科技计划项目(201209)

摘　　要：采用粉末直接压片法,以体外释放度为指标,通过调节缓释骨架材料丙烯酸树脂Ⅱ号用量对处方进行优化,制备头孢拉定缓释片剂,并考察剂型、体外释药试验方法、压片压力,释放介质等对体外累积释放率的影响.结果显示制得的缓释片处方设计合理,工艺重现性好,释药行为符合Weibull方程,体外释放度符合2010版药典规定.Using direct powder compression methods and regarding release rate in vitro as an indicator, the formulations are optimized by adjusting the dosages of sustained-release framework material（Eudragit Ⅱ ）, cefradine sustained-release tablets are prepared and the in- fluences of dosage forms, in vitro drug release experiment, compression force and release media on cumulative release rate have been investigated. Results have shown that the design of sustained-release tablets is reasonable and the reproducibility of the technology is satisfac- tory. In addition, the release behavior is in full accordance with the Weibull equation and the in vitro release rate is consistent with the requirements of Chinese pharmacopeia （Edition 2010）.

关 键 词：头孢拉定 丙烯酸树脂Ⅱ号 骨架材料 缓释片 

分 类 号：R978.1[医药卫生—药品]