生物钟基因对糖代谢的调控影响  

Clock genes＇ regulatory influence to saccharometabolism

作　　者：屠苗英(综述) 王秀敏(审校)[2] 

机构地区：[1]浙江省诸暨市妇幼保健院,311800 [2]浙江大学医学院附属儿童医院内分泌科,杭州310003

出　　处：《国际儿科学杂志》2013年第3期243-246,共4页International Journal of Pediatrics

摘　　要：生物节律是生物界最普遍的生物钟节律，存在于几乎所有的生物体。在哺乳动物及人类，昼夜节律中枢位于下丘脑视交叉上核，在外周组织中也存在节律振荡器，二者通过神经体液联系整合，并与外界同步，对机体的各种生理活动和行为过程进行调控。生物钟的紊乱会造成糖耐量降低，胰岛素分泌异常，导致糖代谢异常。同时葡萄糖、光照、轮班、饮食等原因也可以引起对生物钟时相的移动而影响糖代谢。该文主要综述了生物钟基因对糖代谢的调控影响。Circadian rhythm, as the most common biological rhythm of the biosphere, exists in almost all organisms. The circadian rhythm center of mammals and humans is in the suprachiasmatic nucleus of the hypo- thalamus and circadian oscillation is also found in peripheral organ. By the united integration of neurohumor and external synchronous, these two regulate various physiological activities and behavior processes of organisms. The disturbance of circadian clock causes impaired glucose tolerance and insulin secretory abnormalities, which fur-ther results in abnormal glucose metabolism. Another reason for impaired glucose metabolism is the movement of circadian clock phases caused by glucose, illumination, shift and diet. The review summarizes the clock genes＇ rezulatory influence on saccharometabolism.

关 键 词：生物节律 生物钟基因 糖代谢 

分 类 号：R318.04[医药卫生—生物医学工程]