先天性心脏病表观遗传机制研究进展  

Advances of epigenetic mechanism of congenital heart disease

作　　者：李娈娈[1] 周华斐(综述)[1] 余晓丹(审校)[1] 

机构地区：[1]上海交通大学医学院附属新华医院环境与儿童健康重点实验室,200092

出　　处：《国际儿科学杂志》2013年第3期247-249,253,共4页International Journal of Pediatrics

摘　　要：表观遗传学研究的是除DNA序列改变以外的，在基因表达过程中产生的可遗传的改变。表观遗传学调控机制涉及DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA调控等方面。大量实验研究证明：在心脏发育过程中的表观遗传调控异常可能是导致先天性心脏病的原因。该文从表观遗传学调控所涉及的四个方面探讨先天性心脏病的表观遗传机制进展。Epigenetics refers to the heritable changes in gene expression without an alteration in the DNA sequence of the genome. Epigenetic mechanism involves DNA methylation, histone modification, chromatin remodeling, non-coding RNA regulation and so on. Many experimental investigations indicate that the abnormali-ties in epigenetic regulation during cardiac development may be responsible for the progression of congenital car-diac disease. Based on the four aspects of epigenetic regulation above, this review mainly discusses the advances of epigenetie mechanism of congenital heart disease.

关 键 词：先天性心脏病 表观遗传学 DNA甲基化 组蛋白修饰 染色质重塑 非编码RNA调控 

分 类 号：R541[医药卫生—心血管疾病]