儿童系统性风湿病的胃肠道损害  

Gastrointestinal manifestations of children systemic rheumatic disease

作　　者：李正红[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院儿科,北京100730

出　　处：《国际儿科学杂志》2013年第3期300-303,共4页International Journal of Pediatrics

摘　　要：儿童系统性风湿病常常累及多个系统，胃肠道损害主要为免疫复合物在血管壁的沉积，从而导致缺血和血栓形成。但系统性风湿病的胃肠道损害常因儿童对临床症状的描述不准确、临床表现缺乏特异性、易与药物的胃肠道不良反应相混淆等，而不能得到准确而及时的诊断。与其他系统受累相比，胃肠道损害常不能得到足够的重视，但其后果可能是致命性的，因此早期的诊断和治疗十分关键。该文对常见的儿童系统性风湿病，包括系统性红斑狼疮、过敏性紫癜、白塞病、混合结缔组织病、硬皮病、结节性多动脉炎、韦格纳肉芽肿、干燥综合征及皮肌炎的胃肠道损害进行阐述。Children systemic rheumatic diseases are charactenzed by multisystem involvement, me tm-derlying pathogenesis for gastrointestinal manifestations is deposition of immune complexes in blood vessel walls resulting in ischemia or thrombosis. Gastrointestinal manifestations of these diseases often can＇t be diagnosed ear-ly and correctly ,because children can＇t demonstrate the clinical features accurately ,the clinical manifestation va-ries and often nonspecific, and often confused with the side effect of medicine. Gastrointestinal manifestations are considered rare, comparing with other system involvement, but the consequence can be life-threatening. This makes early and immediate diagnosis and management very important. This paper reviews the various children systemic rheumatic diseases that affect the gastrointestinal tract, including systemic lupus erythematosus, Henoch Schonlein Purpura, Bechet＇s disease, mixed connective tissue disease, scleroderma, polyarteritis nodosa, Wegener＇ s granulomatosis,Siogrn＇s syndrome,dermatomyositis.

关 键 词：儿童 风湿病 胃肠道损害 

分 类 号：R72[医药卫生—儿科]