补肾强督法治疗强直性脊柱炎肾虚督寒证309例的多中心临床观察  

Multicenter clinical observation on the treatment of Bushen Qiangdu of 309 cases of ankylosing spondylitis with kidney deficiency and Du meridian cold syndrome

作　　者：陶庆文[1] 王建明[1] 徐愿[1] 彭建英[2] 邱新萍 杨舒[1] 张艳珍 刘畅 金笛儿[1] 路平[1] 张楠[1] 阎小萍[1] 

机构地区：[1]中日友好医院,北京100029 [2]贵州省安顺市人民医院,安顺561000 [3]北京市顺义区中医医院,北京101300

出　　处：《中华中医药杂志》2013年第6期1722-1726,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中医药行业专项(No.200807031);北京中医药科技项目(No.JJ2011-89)~~

摘　　要：目的:对补肾强督法治疗强直性脊柱炎(AS)肾虚督寒证在不同中心的临床疗效和安全性进行评估。方法:采用前瞻性、多中心、自身前后对照的临床研究方法,3个研究中心共纳入AS肾虚督寒证309例。结果:309例患者经治疗后,腰骶脊背疼痛、活动受限、晨僵、夜间疼痛、腰膝酸软乏力、畏寒喜暖、外周关节肿痛等症状较治疗前改善明显,差异有统计学意义(P<0.01,P<0.05);枕墙距、指地距、颌柄距、Schober试验和脊柱活动度治疗前后有显著性差异(P<0.05),BASG、脊柱痛、BASFI、BASDAI较治疗前改善明显(P<0.05);实验室指标CRP较治疗前改善明显(P<0.05);达到ASAS20标准者147例,占全部病例的47.57%;达到ASAS50者77例,占全部病例的24.92%,达到ASAS70标准者41例,占全部病例的13.27%;达到BASDAI50的患者有25例,占全部病例的8.09%;3个研究中心在研究基线、症状、体征及ASAS20、50、70改善方面未显示显著性差异。结论:补肾强督法治疗AS肾虚督寒证在不同研究中心均显示明确的疗效,且安全可靠,值得临床推广。Objective： To evaluate the clinical efficacy and security of treatment of Bushen Qiangdu on ankylosing spondylitis with kidney deficiency and Du meridian cold syndrome in different centers. Methods： Prospective, multicenter, cross- reference study about 309 cases of ankylosing spondylitis with kidney deficiency and Du meridian cold syndrome from three different research centers were conducted. Results： The clinical symptoms which included pain of lumbar-sacral vertebrae and back, limitation of motion, morning stiffness, nocturnal pain, soreness and weakness of waist and knees, chillness feeling and fondness of warmth, painful swelling of peripheral joints, of 309 patients were relieved dramatically compared with pretherapy, and there were significant differences （P〈0.01, P〈0.05）; distance between occipital bone and wall, distance between fingers and ground, and also the distance between underjaw and presternum spinal mobility, Schober test were significantly improved compared with pretherapy and there were obvious differences （P〈0.05）; BASG, rachialgia, BASFI, BASDAI were significantly improved compared with pretherapy and there was obvious difference （P〈0.05）; the levels of CRP were improved obviously compared with pretherapy （P〈0.05）; there were 147 cases （47.57% of all the cases） up to the standard of ASAS20; 77 cases （24.92% of all the cases） up to the standard of ASAS50, 41 cases （13.27% of all the cases） up to the standard of ASAS70, 25 cases （8.09% of all the cases） up to the standard of BASDAI50; there were no obvious differences in study baseline, symptom, physical sign, and the improvement of ASAS20, 50, 70 simultaneously. Conclusion： There were significant effects and security of ankylosingspondylitis （kidney deficiency and Du meridian cold syndrome） with treatment of Bushen Qiangdu in different research centers, and the result of study was worthy further extending.

关 键 词：补肾强督法 强直性脊柱炎 肾虚督寒证 

分 类 号：R259[医药卫生—中西医结合]