补肾祛斑汤对黄褐斑患者血清P物质、促黑激素及生活质量的影响  

Influence of Bushen Quban Decoction on the level of substance P, melanocyte-stimulating hormone and the quality of life in patients with melasma

作　　者：翁丽丽[1] 单敬文[1] 柯岩[1] 陈华[1] 李晓霞[1] 叶佩真[1] 梅梅[1] 

机构地区：[1]福建中医药大学附属厦门中医院,厦门361009

出　　处：《中华中医药杂志》2013年第6期1899-1901,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：福建省科技厅资助(No.2011D019)~~

摘　　要：目的:探讨补肾祛斑汤对黄褐斑患者血清中P物质(SP)、促黑激素(MSH)和生活质量的影响。方法:将275例辨证为肾虚型的黄褐斑患者按随机数字表法分为治疗组(139例)和对照组(136例)。分别予以90d补肾祛斑汤和维生素C、E药物治疗,并于治疗前后检测两组血清中SP、MSH及记录患者皮肤病生活质量评分。结果:治疗组的SP在治疗后明显下降,且治疗组与对照组相比,有显著性差异(P<0.05);两组的MSH治疗后均下降,二者相比,无显著性差异,治疗前后两组皮肤病生活质量指数(DLQI)评分差值,有显著性差异(P<0.05)。结论:补肾祛斑汤能改善患者生活质量,调节患者血浆神经肽水平。Objective： To explore the clinical effect of Bushen Quban decoction on the level of substance P, melanocyte- stimulating hormone and the quality of life in patients with melasma. Methods： 275 patients were randomly divided into two groups including the Bushen Quban decoction group （139 cases） and the Vitamin C and E group （136 cases）. The level of substance P （SP） and melanocyte-stimulating hormone （MSH） were evaluated before and after the treatment. The quality of life was evaluated for both groups. Results： After 90 days of treatment, the SP changed significantly among the treatment group and control groups （P〈0.05）, but there was no significant change of MSH between two groups. There were significant changes of DLQI between the two groups （P〈0.05）. Conclusion： It was concluded that Bushen Quban Decoction was effective to the melasma by decreasing the level of neuropeptide SP and MSH in plasma. And it could improve the quality of life in patients with melasma.

关 键 词：补肾祛斑汤 黄褐斑 神经肽 生活质量 

分 类 号：R275[医药卫生—中医皮科]