类固醇对鼻息肉中核因子-κB活化的影响  

Effects of glucocorticosteroids on the NF-κB Activity in nasal polyps

作　　者：杜慧敏[1] 徐珏[1] 罗旭东[1] 兰龙江[1] 李满群[1] 马兵良[1] 王建秋[1] 

机构地区：[1]浙江湖州师范学院附属第一人民医院耳鼻咽喉头颈外科,湖州313000

出　　处：《海峡药学》2013年第5期281-283,共3页Strait Pharmaceutical Journal

基　　金：湖州市科技局科技计划项目2009YSB15资助

摘　　要：目的研究糖皮质类固醇激素对鼻息肉中核因子-κB(NF-κB)活化的影响。方法收集2008年2月～2010年9月期间收住本院的准备行鼻息肉切除手术患者的息肉组织标本45例。激素治疗前取鼻腔内的息肉组织作为对照组,布地奈德喷雾剂(BUD)喷鼻,每次2喷,每日2次,治疗7天后行手术切除术,选取切取治疗前钳取组织附近的息肉组织作为治疗组。应用ELISA的方法检测治疗前鼻息肉和使用布地奈德喷鼻剂治疗过后的鼻息肉中的NF-κB的活化情况。结果使用布地奈德喷鼻剂治疗过后的鼻息肉组织匀浆NF-κB活化与治疗前比较明显降低(P<0.05)。结论糖皮质类固醇可抑制鼻息肉组织中NF-κB的活化。OBJECTIVE To study the effects of glucocorticosteroids on the nuclear factor-κB（NF-κB） activity in nasal polyps.METHODS From February 2008 to September 2010,45 polyp tissue samples of patients with nasal polyps before hormone treatment were taken as Control group.Which were treated with Budesonide（BUD） nasal spray,twice daily,treated 7 days before surgical resection.Tissues near the first resection in the surgery were selected as treatment group.NF-κB activity of both groups was determined by ELISA.RESUTLS NF-κB activation were significantly lower in treatment group than that in control group（P 0.05）.CONCLUSION Glucocorticosteroids can inhibit the NF-κB activity in the nasal polyps.

关 键 词：类固醇 鼻息肉 核因子-ΚB 活化 

分 类 号：R969.4[医药卫生—药理学]