白藜芦醇在抗衰老领域的研究进展  

Recent progress of resveratrol in anti-aging field

作　　者：李博[1] 宁光[1] 张志国[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科、上海内分泌代谢病研究所、上海市内分泌代谢病l临床医学中心,200025

出　　处：《国际内分泌代谢杂志》2013年第3期189-191,198,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目，曙光跟踪

摘　　要：白藜芦醇是一种存在于中药虎杖、葡萄以及红酒中的多酚类化合物。既往研究表明，热量限制具有抗衰老的作用。近年研究发现，白藜芦醇能模拟热量限制，在抗衰老领域发挥积极的作用，并且具有抗糖尿病、保护心血管和神经功能的作用；白藜芦醇的生物学靶点和作用机制也开始被了解。同时，白藜芦醇临床试验所获得的疗效及安全性研究结果为其将来临床应用打下了基础。Resveratrol is a polyphenol compound originally extracted from giant knotweed,grape,and red wine. Previous research demonstrated calorie restriction has anti-aging effect. Recent studies showed that resveratrol could mimick calorie restriction, thereby play an positive role in anti-aging field. Moreover, it has anti-diabetic, cardioprotective and neuroprotective effects as well. The potential targets and the underlying mechanisms of resveratrol have begun to be elucidated. Meanwhile,accumulating data of its effectiveness and safety from clinical studies also contribute to pave the way for its further clinical application.

关 键 词：白藜芦醇 衰老 热量限制 

分 类 号：R285.5[医药卫生—中药学]