阿托伐他汀对慢性心力衰竭患者QT离散度及N末端脑钠肽前体的影响  

To study the effects of atorvastatin on QTd and NT-proBNP in Patients with chronic heart failure

作　　者：王记[1,2] 姚亚利[1] 

机构地区：[1]兰州大学第一临床医学院心血管科,甘肃兰州730000 [2]甘肃中医学院附属医院,甘肃兰州730000

出　　处：《甘肃医药》2013年第5期329-331,共3页Gansu Medical Journal

摘　　要：目的:观察阿托伐他汀对慢性心力衰竭(CHF)患者QT离散度(QTd)及N末端脑钠肽前体(NT-proBNP)的影响,从而探讨其机制。方法:将70例慢性心力衰竭患者随机分为2组,对照组35例按目前相关指南给予常规治疗,治疗组35例在常规治疗的基础上加用阿托伐他汀。患者均连续服药12周后,观察2组治疗前后血清NT-proBNP水平和QT离散度的变化。结果:(1)治疗后,治疗组较常规组QTd及QTcd表现出下降趋势。(2)治疗后,两组血清NT-proBNP均明显下降,治疗组与对照组治疗后比较差异也有统计学意义。结论:阿托伐他汀可明显改善慢性心力衰竭患者的预后。Objective：To study the effects of atorvastatin on QTd（qt dispersion） and NT-proBNP in Patients with chronic heart failure;Methods：70 Patients with chronic heart failure were randomly divided into two groups,35 patients were treated with Conventional therapy as control group;35 patients were treated with combination therapy of atorvastatin with Conventional therapy as treatment group.QTd and NT-proBNP levels were measured before and after 12 week treatmeant;Results：（1） in two groups,QTd and QTcd levels were both significantly reduced after treatment,especially in treatment group.（2）After treatment,NT-proBNP in blood plasma was decreasing significantly in treatment group,Compared with control group,the decreasing was significantly（.P0.05）.Conclusion：atorvastatin treatment significantly improve the prognosis of the patients with chronic heart failure.

关 键 词：慢性心力衰竭 阿托伐他汀 QT离散度 NT-PROBNP 

分 类 号：R541.61[医药卫生—心血管疾病]