1,3-二环己基碳化二亚胺(DCC)为脱水剂低温合成丙炔酸酯的研究  

Synthesis of propiolic acid ester by dicyclohexylcarbodiimide(DCC) as dehydrating agent at low temperature

作　　者：史建华[1] 王辉[1] 盛含晶[1] 冯燕[1] 盛鸿婷[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《应用化工》2013年第5期787-790,共4页Applied Chemical Industry

基　　金：国家自然科学基金资助项目(20902001);安徽省自然科学基金资助项目(090416220)

摘　　要：以丙炔醇为原料,氧化合成丙炔酸,在1,3-二环己基碳化二亚胺(DCC)脱水剂作用下,低温合成丙炔酸酯。与传统浓硫酸催化酯化相比,本方法副反应少、产率高。并且发现丙炔酸酚酯的产率与酚上取代基团存在关系,对位为给电子取代基的酚类,能获得更高的产率。并用此法首次高选择性的合成出丙炔酸双酯。Propiolic acid was synthesized by the oxidation of propiolic alcohol, and propiolic acid ester was synthesized by dicyclohexylcarbodiimide（DCC） as dehydrating agent at low temperature. Compared with the traditional esterification by the sulfuric acid as dehydrating agent, this method had less side reaction and obtained high yield. And found that the yield of propiolic acid ester was related with the substituted groups on the phenols, high yield of propiolic acid ester was obtained when the phenols＇ para-position ex- isted electron-donating substituent. And it also firstly used such method to synthesize bilateral propiolic acid ester in the high selectivity.

关 键 词：丙炔酸 DCC 脱水 丙炔酸酯 

分 类 号：TQ226.4[化学工程—有机化工] O625.64[理学—有机化学]