嘧啶胍的合成及生物活性  

Synthesis and biological activities of guanidine substituted pyrimidine

作　　者：谢斌[1] 孙晓红[2] 刘源发[3] 陈邦[3] 马海霞[4] 

机构地区：[1]陕西省西安植物园,陕西西安710061 [2]西北大学化学研究所,陕西西安710069 [3]西北大学化学与材料学院,陕西西安710069 [4]西北大学化工学院,陕西西安710069

出　　处：《应用化工》2013年第5期809-813,共5页Applied Chemical Industry

基　　金：国家自然科学基金资助项目(21073141;31200257);陕西省科学院科技计划项目(2012K-01);陕西科技统筹创新工程计划项目(2012KTCL02-07)

摘　　要：以嘧啶为起始原料,酸化后和单氰胺反应生成五种具有生物活性的嘧啶胍。通过红外光谱(IR)、核磁共振(1H NMR)、元素分析和熔点测定确定了各化合物的结构,研究了化合物对小麦赤霉病、烟草赤星病、西瓜枯萎病、马铃薯干腐病4种植物病原菌的生物活性,得到毒力回归方程及相关性系数、EC50和EC95值;还对小麦和萝卜生长调节的活性进行了研究。结果表明,该类化合物具有较好的抑菌活性和植物生长调节活性。Five biological active pyrimidine guanidines were synthesized by using pyrimidine and cyanamide under acidification. Their structures were confirmed by infrared spectra （IR）, nuclear magnetic resonance spectroscopy （^ 1 H NMR） elemental analysis and melting point measurement. The biological activi- ties to the four vegetable pathogens of Gibberlla saubinetii, Gibberlla nicotiancola, Fusarium oxysporium f. s. p. niveum, Pythium solani were tested, the toxic regression equation and correlation coefficient were obtained,the ECs0 and EC95 were calculated;the growth regulation activities to wheat and radish were also tested. The results show that such compounds exhibit good fungicidal activities and plant growth activities.

关 键 词：嘧啶 胍类化合物 合成 生物活性 

分 类 号：O621.3[理学—有机化学]