不稳定的二甲基氨基甲基二茂铁的ESI-HRMS分析条件研究  

Study on Analytic Condition for Labile N,N-dimethylaminomethyl Ferrocene by ESI-HRMS

作　　者：姬红凯[1] 于俊[1] 朱登勇[1] 许丽君[1] 贾伟伟[1] 张建业[1] 

机构地区：[1]郑州大学化学与分子工程学院,河南郑州450001

出　　处：《分析测试学报》2013年第5期565-569,共5页Journal of Instrumental Analysis

基　　金：郑州大学校研究生教育支持基金

摘　　要：研究并优化了化合物N,N-二甲基氨基甲基二茂铁的电喷雾离子化-高分辨质谱(ESI-HRMS)分析方法。重复测定样品,目标分子离子计数的相对标准偏差(RSD,n=10)为2.4%,表明仪器重复性良好。通过对目标分子的一级质谱图与二级质谱图分析,一级质谱图中母离子的丰度低于最强子离子丰度的10%,表明目标分子在源内发生了裂解。研究了一级质谱中目标分子离子及其最强碎片离子的离子计数与干燥气温度、毛细管出口电压的变化规律,并拟合得到相应的数学方程;确定了目标分子质谱分析的最佳条件。An electrospray ionization-high resolution mass spectrometric（ESI-HRMS） method was developed for the determination of thermolabile N,N-dimethylaminomethyl ferrocene compounds.The relative standard deviation（RSD,n=10） for the ion counts of the target molecule was 2.4%.By analysis of the MS spectrum and MS/MS spectrum of the target molecule,it is showed that an in-source dissociation of the target molecule took place with the abundance of the mother ion being less than 10% of the abundance of the main daughter ion in the MS spectrum.The relevance of ion counts of the target molecule and its main daughter ion with temperature of the drying gas and voltage of the capillary export（Fragmentor） were investigated,respectively.Furthermore,corresponding fitting mathematical equations were established,and the optimum analytical conditions of the target molecule by ESI-HRMS were obtained.

关 键 词：电喷雾离子化-高分辨质谱 Q-TOF质谱 N N-二甲基氨基甲基二茂铁 

分 类 号：O657.63[理学—分析化学] R282[理学—化学]