整合素及其调控破骨细胞相关信号机制研究进展  

Study on Integrin and Its Signal Modulating Mechanisms of Osteoclast

作　　者：仝锡帅[1] 顾建红[1] 刘宗平[1] 

机构地区：[1]扬州大学兽医学院,江苏扬州225009

出　　处：《动物医学进展》2013年第5期99-102,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(30972229;31172373);高等学校博士学科点专项基金项目(20113250110003)

摘　　要：整合素是一类细胞膜表面跨膜蛋白,在介导细胞黏附并参与细胞内外信号传递的过程中具有重要意义。破骨细胞在骨重建与骨吸收的动态平衡中起关键调控作用,尤其是封闭带中的整合素αvβ3是影响骨吸收的主要黏附分子,对破骨细胞内外Ca2+及下游信号的调控起关键作用。论文对整合素的结构、分类、功能及其调控破骨细胞相关信号的机制进行了阐述。Integrins are cell membrane surface transmembrane receptors that mediate the attachment between a cell and the tissues that surround it. They are involved in cell signaling and the regulation of cell cycle, shape and motility. Osteoclast plays a key role in the dynamic balance of bone remodeling and bone absorption, especially integrin αvβ3 of sealing zone is the major adhesion molecule and has effect on bone resorption and regulation of intraceUular and extracellular Ca2＋ in the osteoclast and downstream signaling. In this mini-review, we mainly focused on narrativing the structure, the classification, the function of integrin and the related signal regulating mechanisms of osteoclast.

关 键 词：整合素 破骨细胞 信号转导 

分 类 号：S852.2[农业科学—基础兽医学]