食欲抑制剂和药物诱导的肺动脉高压  

Appetite suppressants and drugs associated pulmonary arterial hypertension

作　　者：吴丹辰[1] 程春燕[1] 荆志成[1,2] 

机构地区：[1]同济大学附属上海市肺科医院心肺循环中心,上海200433 [2]中国医学科学院北京协和医学院国家心血管病中心阜外心血管病医院心血管疾病国家重点实验室,北京100037

出　　处：《世界临床药物》2013年第5期266-270,共5页World Clinical Drug

摘　　要：上世纪60年代起,食欲抑制剂与肺动脉高压(PAH)的相关性引起关注。本文综述食欲抑制剂和药物导致的PAH的流行病学资料、临床研究及其导致PAH发病的机制假说,探讨其疾病进展及预后。In the 1960s,the use of appetite suppressants caused a transient incident of pulmonary arterial hypertension in western countries.Since then the case reports and basic researches have revealed a close relationship between appetite suppressants and pulmonary arterial hypertension.This review describes the epidemic features and clinical studies on appetite suppressant and drug induced pulmonary arterial hypertension,as well as the underlying mechanisms.The progression and prognosis of the disease also be discussed.

关 键 词：肺动脉高压 食欲抑制剂 不良反应 

分 类 号：R544.16[医药卫生—心血管疾病] R977.9[医药卫生—内科学]