吡唑醚菌酯的合成和初步生物活性  

Synthesis and Biological Activities of Pyraclostrobin

作　　者：马海军[1] 曹庆亮[1] 马亚芳[1] 倪珏萍[1] 

机构地区：[1]f江苏省农药研究所股份有限公司江苏南方农药研究中心,南京210046

出　　处：《农药》2013年第6期408-410,共3页Agrochemicals

摘　　要：[方法]吡唑醚菌酯属甲氧基丙烯酸酯类杀菌剂,具有优良的生物活性,以邻硝基甲苯和对氯苯胺为起始原料,经重氮化、环合、氧化、溴化、缩合、还原、酰化、甲基化等工艺制备吡唑醚菌酯。[结论]以对氯苯胺计总收率大于55%,产品纯度大于95%。该工艺具有生产成本低、操作简便和易于工业化生产等特点。吡唑醚菌酯对小麦赤霉病和水稻纹枯病具有优良离体活性。Pyraclostrobin is a strobilurin fungicide with excellent biological activties. A preparation method of pyraclostrobin was described by using o-nitrotoluene and p-chloroaniline as raw materials including diazotization, cyclization, oxidation, bromination, condensation, reduction, acetylation and methylation. [Conclusions] The total yield was more than 55% based on p-chloroaniline, and the purity was higher than 95%. This process was easy to be industrialized with lower cost. Pyraclostrobin have a good fungicidal activity in vitro against wheat scab （Gibberella zeae） and rice sheath blight disease（Rhizoctonia solani）.

关 键 词：吡唑醚菌酯 合成 邻硝基甲苯 对氯苯胺 生物活性 

分 类 号：TQ455.4[化学工程—农药化工]