胰岛素抵抗在老老年高血压与青年高血压患者中的不同特点  

The Difference of Insulin Resistance between Very Elderly and Young Patients with Hypertension

作　　者：王兵[1] 赵良平[1] 陈建昌[1] 徐卫亭[1] 李建凤[1] 顾海波[1] 李晖[1] 古小松[1] 

机构地区：[1]苏州大学附属第二医院心脏内科,江苏苏州215004

出　　处：《中国血液流变学杂志》2013年第1期39-42,共4页Chinese Journal of Hemorheology

基　　金：苏州市科技发展计划指导项目（SYSD2010128）;苏州市科教兴卫计划项目（2011011）

摘　　要：目的分析胰岛素抵抗（IR）在老老年高血压与青年高血压患者中的不同特点.方法连续入选老老年高血压患者98例,同期入选98例青年高血压患者.测定空腹血糖、空腹血浆胰岛素等.用自我平衡模型分析法（HOMA）指数（IRI）评价胰岛素抵抗.治疗并随访6个月.进行相关数据统计分析.结果老老年高血压组患者的血脂水平与体质指数显著低于青年高血压组（P〈0.05）,而空腹血糖、空腹血浆胰岛素、IRI以及IRI≥2.69比例两组间无显著差异.有效治疗后,青年高血压组的IRI下降值明显高于老老年高血压组（P〈0.05）.结论在非糖尿病人群,老老年高血压患者的IR程度与青年高血压患者无明显差异,但青年高血压患者的IR更易改善.Objective To discuss the difference of insulin resistance（IR） between very elderly and young patients with hypertension.Methods 98 consecutive very elderly patients with hypertension were enrolled in this study,and 98 young patients with hypertension as the control.The metabolic parameters and homeostasis model assessmem for IR（IRI） were measured.The patients were treated and followed up for 6 months.Results Fasting blood glucose,plasma insulin level,and IRI were similar between the two groups.The triglyceride,total cholesterol,low density lipoprotein,body mass index were significantly lower in very elderly patients with hypertension.IRI in young hypertension was decreased faster after effective treatment.Conclusion The degree of IR was similar between very elderly hypertension and young hypertension without diabetes.But IR in young hypertension was ameliorated faster after effective treatment.

关 键 词：胰岛素抵抗 老老年高血压 青年高血压 

分 类 号：R544.1[医药卫生—心血管疾病]