血清IgA、C3及IgA／C3比值在IgA肾病中的临床意义  

Clinical Significance of Serum IgA,C3 Levels and IgA/C3 Ratio in IgA Nephropathy

作　　者：鲍玲玲[1] 柴华旗[1] 

机构地区：[1]苏州大学附属第一医院肾内科,江苏苏州215006

出　　处：《中国血液流变学杂志》2013年第1期78-81,共4页Chinese Journal of Hemorheology

摘　　要：目的探讨血清IgA、C3水平及IgA/C3比值在原发性IgA肾病中的临床意义.方法以透射免疫比浊法测定69例经肾穿刺活检确诊为原发性IgA肾病患者和58例非IgA原发性肾小球肾炎患者血清IgA及C3水平,按Haas分级标准评估IgA肾病的病理分型,同时对结果进行分析.结果原发性IgA肾病患者与非IgA原发性肾小球肾炎患者血清IgA水平分别为[（3.01±0.91）vs（2.51±1.05）g/L,P〈0.01];血清C3水平分别为[（1.00±0.22）vs（1.14±0.27）g/L,P〈0.01];IgA/C3比值分别为（3.14±1.19 vs 2.26±0.93,P〈0.01）.Haas分型为Ⅰ、Ⅱ型患者与Ⅲ、Ⅳ、Ⅴ型患者血清IgA水平分别为[（2.87±0.82）vs（3.26±1.03）g/L,P〉0.05];血清C3水平分别为[（0.98±0.20）vs（1.04±0.25）g/L,P〉0.05];IgA/C3比值分别为（3.05±1.03 vs 3.31±1.45,P〉0.05）.结论血清IgA、C3水平及IgA/C3比值可作为鉴别原发性IgA肾病与非IgA肾病的参考指标.Objective To analyze the difference of serum IgA,C3 levels and IgA/ C3 ratio between the patients with primary IgA nephropathy（IgAN） and non-IgA nephropathy and observe the correlation of these parameters with Haas＇s grading system in patients with IgA nephropathy.Methods 69 patients with primary IgA nephropathy and 58 patients with non-IgA nephropathy were diagnosed by renal biopsy,the levels of serum IgA,C3 were detected with turbidimetric method in all patients.Patho-grading was evaluated according to the standard of Haas grading.Results The levels of serum IgA in the patients with IgAN were significantly higher than those in patients with non-IgA nephropathy（3.01±0.91 vs 2.51±1.05g/L,P〈0.01）,and the serum C3 levels in the patients with IgAN were significantly lower than those in patients with non-IgA nephropathy（1.00±0.22 vs 1.14±0.27g/L,P〈0.01）,the IgA/ C3 ratio in IgAN group was also significantly higher than that in non-IgA group（3.14±1.19 vs 2.26±0.93,P〈0.01）.The serum IgA（2.87±0.82 vs 3.26±1.03g/L,P〉0.05）,C3 levels（0.98±0.20 vs 1.04±0.25g/L,P〉0.05） and IgA/ C3 ratio（3.05±1.03 vs 3.31±1.45,P〉0.05） of the patients with class Ⅲ,Ⅳ,Ⅴ was higher than classⅠand Ⅱ,but the differences between groups was not statistically significant.Conclusion The serum IgA,C3 levels and IgA/ C3 ratio could be used as reference parameter to identify primary IgA nephropathy from non-IgA nephropathy.

关 键 词：IGA肾病 血清IGA 血清C3 IGA C3比值 

分 类 号：R692.6[医药卫生—泌尿科学]