N-端脑利钠肽前体测定对急性心肌梗死早期诊断的临床意义  

Clinical significance of NT-proBNP in early diagnosis of acute myocardial infarction

作　　者：熊宁[1] 刘俊[1] 彭志群[1] 吴珊燕[1] 王强[1] 

机构地区：[1]解放军第184医院心内科,江西鹰潭335000

出　　处：《临床军医杂志》2013年第5期452-453,共2页Clinical Journal of Medical Officers

摘　　要：目的观察急性心肌梗死(AMI)患者血清N-末端脑利钠肽前体(NT-proBNP)与肌钙蛋白Ⅰ(cTnⅠ)浓度,探讨NT-proBNP对AMI早期诊断的临床意义。方法采用免疫定量分析仪和配套试剂测定AMI患者血清NT-proBNP与cTnⅠ的浓度,分析两者之间的相关性。结果 AMI患者血清NT-proBNP浓度高于健康对照组,差异有统计学意义。AMI患者cTnⅠ浓度与NT-proBNP浓度呈正相关。结论 NT-proBNP水平的测定可以为AMI患者的早期诊断、病情监测等提供客观依据。Objective To observe the concentration of N-terminal pro-brain natriuretic peptide （NT-proBNP） and cardiac troponin I （ cTn I ） in acute myocardial infarction （AMI） patients, and discuss the clinical significance of NT-proBNP in the early diagnosis of AMI. Methods The concentrations of NT-proBNP and cTn I in serum were detected by immunohistochemical quantitative ana- lyzer and supporting reagents in AMI patients and the correlation was analyzed. Results The concentration of NT-proBNP in AMI group was higher than that in healthy control group （P 〈 0.05）. In the AMI group, there was a positively correlation between the concentrations of cTn I and that of NT-proBNP. Conclusion NT-proBNP level can be used to provide an objective basis in the early diagnosis and monitoring of AMI.

关 键 词：急性心肌梗死 N-末端脑利钠肽前体 肌钙蛋白I 

分 类 号：R542.22[医药卫生—心血管疾病]