吡咯列酮联合瑞格列奈治疗外源性胰岛素抗体阳性的2型糖尿病肾病观察  被引量:1

Observation on pioglitazone combined with repaglinide for treatment of external insulin antibody positive patients with type 2 diabetic nephropathy

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作  者:刘智梅[1] 

机构地区:[1]杭州市江干区人民医院内分泌科,浙江省杭州310016

出  处:《中国基层医药》2013年第9期1326-1328,共3页Chinese Journal of Primary Medicine and Pharmacy

摘  要:目的 观察吡咯列酮联合瑞格列奈治疗外源性胰岛素抗体阳性的2型糖尿病肾病的疗效。方法 将44例外源性胰岛素抗体阳性的糖尿病肾病患者分成治疗组(22例)和对照组(22例),治疗组停用胰岛素改为吡咯列酮15 mg,每天1次,瑞格列奈1 mg,每天3次,口服并逐渐调正剂量,对照组胰岛素,共治疗12周,治疗前后测定血糖、血脂、糖化血红蛋白等。结果 2型糖尿病肾病患者经口服吡咯列酮联合瑞格列奈治疗后血糖、糖化血红蛋白、尿白蛋白与尿肌酐比值等较前均有显著降低(均P〈0.01),上述指标与对照组治疗后同期差异有统计学意义(P〈0.05)。结论 吡咯列酮联合瑞格列奈应用是治疗外源性胰岛素抗体阳性的2型糖尿病肾病的有效方法。Objective To observe the efficacy of pioglitazone combined with repaglinide in the treatment of external insulin antibody (IAb)-positive patients with type 2 diabetic nephropathy.Methods 44 cases with IAb positive diabetes nephropathy were divided into the treatment group(22 cases) and control group(22 cases).The treatment group moved gradually insulin to pioglitazone 15 mg once daily add repaglinide 1 mg three times daily oral and gradually adjustment dose.The control group continued to use insulin treatment,a total of 12 weeks.Before and after treatment,blood sugar,blood fat,glycosylated hemoglobin,etc were detected.Results After treatment,the blood glucose,glycosylated hemoglobin,urine albumin and urine creatinine ratio of the treatment group were significantly decreased (all P〈0.01),the above indicators had statistically significant differences compared with the control group at the same period (P〈0.05).Conclusion Pioglitazone combined with repaglinide is an effective method for treatment of IAb positive type 2 diabetic nephropathy.

关 键 词:糖尿病肾病 胰岛素抗体 吡咯列酮 瑞格列奈 

分 类 号:R587.1[医药卫生—内分泌]

 

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