磷酸三钙涂层镁合金材料的体内降解及组织相容性研究  

In Vivo Degradation and Biocompatibility of Magnesium Alloy Coated with Tricalcium Phosphate

作　　者：赵杰[1] 郭磊[1] 付玉平[1] 赵延刚[1] 谭丽丽[2] 杨柯[2] 

机构地区：[1]中国医科大学附属第一医院,辽宁沈阳110001 [2]中国科学院金属研究所,辽宁沈阳110016

出　　处：《稀有金属材料与工程》2013年第5期1013-1016,共4页Rare Metal Materials and Engineering

基　　金：国家自然科学基金(30872724;81071460)

摘　　要：探讨新型医用金属材料磷酸三钙（β-TCP）涂层镁合金的体内降解特性和生物活性,制备β-TCP涂层镁合金（β-TCP-Mg-Al-Zn）并植入大鼠股骨骨髓腔,扫描电镜观察体内植入材料的表面微观结构及材料表面能谱,分析材料表面钙（Ca）和磷（P）元素的变化规律。结果表明,材料体内植入1~4w时,（β-TCP）-Mg-Al-Zn材料表面有大量的粘附蛋白物质;材料体内植入8w时,（β-TCP）-Mg-Al-Zn材料表面Ca和P元素含量明显高于Mg-Al-Zn材料（P〈0.05）;体内植入12w时,Mg-Al-Zn材料降解约33%,而（β-TCP）-Mg-Al-Zn材料降解率为17%。β-TCP涂层可有效地延缓Mg-Al-Zn镁合金的体内降解,并使Mg-Al-Zn材料表面具有良好的生物活性。The superficial degradation in vivo and biocompatibility of magnesium alloy （Mg-Al-Zn） coated with tricalcium phosphate （β-TCP） have been evaluated. （β-TCP）-Mg-Al-Zn implants were made and implanted into the femur of rats. The surface microstructure observation of implants and the EDS analysis were carried out. The changes of Ca and P on the surface of the implants were analyzed. Results show that many attachment proteins appear in the surface of （β-TCP）-Mg-Al-Zn after 4 weeks implantation. In the 8th week, the content of Ca and P in the surface of （β-TCP）-Mg-Al-Zn are higher than that in naked Mg-Al-Zn （P0.05）. In the 12th week, about 33 % of naked Mg-Al-Zn alloy is degraded, while 17 % of （β-TCP）-Mg-Al-Zn is degraded. β-TCP coating can decay the superficial degradation and improve the biocompatibility of Mg-Al-Zn matrix in vivo.

关 键 词：镁合金 磷酸三钙 涂层 体内降解 生物活性 

分 类 号：R318.08[医药卫生—生物医学工程]