Adr型HBV全基因转基因小鼠DC和T细胞功能的研究  

Study for the Functions of T Cell and DCs in the Adr Type HBV Transgenic Mouse

作　　者：邵启祥[1] 王文红[1] 许化溪[1] 傅翠梅[1] 李良菊[1] 沈关心[2] 刘恭植[1] 

机构地区：[1]镇江医学院免疫学研究室,江苏镇江212001 [2]同济医科大学免疫学教研室,湖北武汉430000

出　　处：《镇江医学院学报》2000年第2期217-218,共2页Journal of Zhenjiang Medical College

基　　金：江苏省科委应用基础资助!(BJ990 4 1 );江苏省教委资助!(98KJD31 0 0 4 # )

摘　　要：目的方法 :通过对分离Adr型HBV全基因转基因小鼠的脾脏淋巴细胞和树突状细胞 ,并研究其对ConA ,HBeAg ,ConA +HBeAg刺激的应答能力。结果 :发现HBV转基因小鼠对ConA的应答基本正常 ,但对HBeAg ,ConA +HBeAg的应答明显低于对照组 ,说明HBV转基因小鼠DC和T细胞对HBV存在特异性的免疫耐受。Objective: To investigate the function of dendritic cell and T lymphocytes of the Adr type hepatitis B Virus (HBV) transgenic mice. Methods: Isolating the dendritic cells and lymphocytes from spleen of hepatitis B Virus (HBV) transgenic mice, and study the responsing level after stimulating with the ConA, HBeAg, ConA+HBeAg respectively. Results: The responsing function of the dendritic cells and T lymphocytes of hepatitis B Virus (HBV) transgenic mice is normal when it stimulated by ConA, but its function is lower when it stimulated by HBeAg, ConA+HBeAg. Conclusions: The dendritic cells and T lymphocytes may tolerate to the HBV in the hepatitis B Virus (HBV) transgenic mice.

关 键 词：HBV 转基因小鼠 HBEAG DCT细胞 免疫耐受 

分 类 号：R373.21[医药卫生—病原生物学]