血尿酸和超敏C反应蛋白与冠心病心脏性猝死的相关性研究  

Study on the correlation between the level of serum uric acid and high-sensitivity C-reactive protein with sudden cardiac death of coronary artery disease

作　　者：邹晖[1] 李晓杰[1] 王欣[1] 蔡胜男[1] 

机构地区：[1]黑龙江省医院心血管内科,黑龙江省哈尔滨150036

出　　处：《中国基层医药》2013年第11期1604-1605,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：黑龙江省卫生厅科研课题（2012-356）

摘　　要：目的 探讨血尿酸和超敏C反应蛋白水平与冠心病心脏性猝死的关系。方法 收集80例冠心病患者的临床资料,根据是否出现冠心病心脏性猝死分为观察组（冠心病心脏性猝死组）和对照组（冠心病非猝死组）,每组40例。比较两组患者的血尿酸（UA）、低密度脂蛋白胆固醇（LDL-C）、血糖、超敏C反应蛋白（hs-CRP）的检测结果。结果 观察组男性、女性的血UA、hs-CRP水平分别为（444.06±36.44.）μmol/L、（7.29±0.57）mg/L、（399.25±9.91）μmol/L、（6.56±0.38）mg/L,均明显高于对照组的（289.40±25.78）μmol/L、（1.04±0.11）mg/L、（209.90±29.87）μmol/L、（1.22±0.31）mg/L（t=－15.49、－47.71、－26.90、－47.92,均P〈0.01）。两组同性别间LDL-C、血糖水平差异均无统计学意义（t=－1.34、－1.54、－1.06、－1.33,均P〉0.05）。结论 血尿酸水平和超敏C反应蛋白水平升高与冠心病心脏性猝死有关。Objective To explore the correlation between the level of serum uric acid （UA） and high-sensitivity C-reactive protein（hs-CRP） with sudden cardiac death of coronary artery disease.Methods Clinical data of 80 patients with coronary artery disease were collected,and according to whether occurred coronary heart sudden cardiac death,the patients were divided into the observation group（coronary heart disease with sudden cardiac death group） and the control group（coronary heart disease with non-sudden death group）,each group had 40 cases.The levels of serum UA,low-density lipoprotein cholesterol（LDL-C）,blood sugar, hs-CRP of the two groups were detected and compared.Results The UA and hs-CRP levels of male and female in the observation group were （444.06±36.44.）μmol/L,（7.29±0.57）mg/L,（399.25±9.91）μmol/L,（6.56±0.38）mg/L,respectively,which were significantly higher than those in the control group[（289.40±25.78）μmol/L,（1.04±0.11）mg/L,（209.90±29.87）μmol/L,（1.22±0.31）mg/L]（t=-15.49,-47.71,-26.90,-47.92,all P〈0.01）.There were no statistically significant differences in the levels of LDL-C and blood glucose between the same sex of the two groups（t=-1.34,-1.54,-1.06,-1.33,all P〉0.05）.Conclusion The increased levels of serum UA and hs-CRP may be associate with sudden cardiac death of coronary artery disease.

关 键 词：血尿酸 C反应蛋白质 冠心病 猝死 心脏 预后 

分 类 号：R541.4[医药卫生—心血管疾病]